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- W2588058291 abstract "Humanization of autoantigen is a new concept in research on autoimmune diseases. Mouse models whose phenotypic features closely reproduce those of human skin diseases are important to our understanding of the pathomechanisms of those diseases as well as to developing novel, efficient therapeutic strategies. In some autoimmune diseases, the transfer of patient autoantibodies to normal mice leads to the development of a clinical phenotype that corresponds to respective disease. However, for some autoimmune diseases, such as bullous pemphigoid (BP), the transfer of patient autoantibodies fails to generate the clinical phenotype, due to inter-species differences in the amino acid sequences of autoantigens. To overcome this problem, we have humanized the mouse BP autoantigen molecule to its human amino acid sequence. The transfer of human BP autoantibodies to BP autoantigen-humanized mice successfully generates a clinical phenotype corresponding to BP (Nishie et al., Nat Med 2007). This lecture introduces several new discoveries made using such animal models (J Immunol 2009, J Immunol 2010, Am J Pathol 2010)." @default.
- W2588058291 created "2017-02-24" @default.
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- W2588058291 date "2010-08-01" @default.
- W2588058291 modified "2023-10-16" @default.
- W2588058291 title "Humanization of autoantigen to develop novel mouse models of autoimmunity (LL5-3)" @default.
- W2588058291 doi "https://doi.org/10.1093/intimm/dxq215" @default.
- W2588058291 hasPublicationYear "2010" @default.
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