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- W2588068787 abstract "The evaluation and follow-up of patients with high grade glioma undergoing treatment continues to be a challenge. Glioblastoma is a highly vascular tumor and there is a need to assess angiogenesis in the course of treatment as response is monitored. ASL is a noninvasive perfusion imaging method which uses blood water as an infusible endogenous tracer. Serial MRI with ASL of 13 patients with treated glioma followed longitudinally over time were reviewed. There were 7 cases of glioblastoma, 2 anaplastic astrocytomas, 1 optic glioma, 2 low grade oligodendrogliomas, and 1 low grade astrocytoma. All patients were followed by serial brain MRI, including ASL using 3D pCASL (pseudo-continuous ASL) obtained prior to gadolinium contrast administration. CBF maps (in ml/100gm/min.) were created from ASL data, and maximum CBF measurements were recorded and correlated to enhancing and non-enhancing regions of treated glioma. Elevated CBF values correlated with tumor progression and at times ante-dated changes seen on contrast-enhanced MRI or FLAIR. These regions of increased CBF were typically surrounded by a halo of relatively decreased CBF, probably background of treated tumor. Bland regions of relatively low CBF correlated with treatment effect when contrast-enhanced images suggested tumor progression. Increased CBF from a seizure focus in peri-ictal state can be misinterpreted as tumor progression. ASL is an emerging MRI technique that provides quantitative CBF measurements without contrast administration, ideal for following patients diagnosed with high grade glioma undergoing treatment. It may be helpful in the setting of a patient with suspicious progression on contrast MRI and fluid attenuated inversion recovery (FLAIR) sequences and no neurological progression, for whom treatment decisions need to be made." @default.
- W2588068787 created "2017-02-24" @default.
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- W2588068787 date "2016-11-01" @default.
- W2588068787 modified "2023-09-27" @default.
- W2588068787 title "NIMG-59. MAGNETIC RESONANCE IMAGING SEQUENCE ARTERIAL SPIN LABELING (ASL) IN THE MONITORING OF PATIENTS WITH GLIOMA: AN AID IN DETERMINING PROGRESSION VS. TREATMENT CHANGE" @default.
- W2588068787 doi "https://doi.org/10.1093/neuonc/now212.570" @default.
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