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- W2588122889 abstract "The objective was to evaluate the in silico, in vitro and in vivo effects of a black bean hydrolyzed protein isolate (HPI) and its pure peptides on glucose absorption. By interacting with their protein motif, pure peptides blocked glucose transporters GLUT2 and SGLT1. HPI (10 mg/mL) reduced formation of intracellular oxygen reactive species by 71%. Glucose absorption decreased 21.5% after 24 h treatment when using the Caco-2 cell model. Oral glucose tolerance test in rats showed a 24.5% decrease on postprandial glucose (p < 0.05) (50 mg HPI /kg BW). In the hyperglycemic rat model, HPI caused a reduction of blood glucose, in a dose-dependent manner. The lowest fasting glucose was found in rats receiving 150 and 200 mg/kg BW/day HPI, (p < 0.05). The black bean HPI is an inexpensive food source of bioactive compounds that could be used in the management of blood glucose." @default.
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- W2588122889 date "2017-04-01" @default.
- W2588122889 modified "2023-10-18" @default.
- W2588122889 title "Evaluation of the hypoglycemic potential of a black bean hydrolyzed protein isolate and its pure peptides using in silico, in vitro and in vivo approaches" @default.
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- W2588122889 doi "https://doi.org/10.1016/j.jff.2017.02.006" @default.
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