Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588136719> ?p ?o ?g. }
Showing items 1 to 49 of
49
with 100 items per page.
- W2588136719 endingPage "iv72" @default.
- W2588136719 startingPage "iv72" @default.
- W2588136719 abstract "AbstractPurpose:Both surgery and radiosurgery (SRS) are frequently used in the initial management of patients with brain metastases. We have evaluated the local control and the radiation-induced brain necrosis in patients with large resistant brain metastases (>2 cm in size) who received multi-fraction stereotactic radiosurgery (MF-SRS) or surgery followed by MF-SRS.Patients and Methods:Patients with renal cell carcinoma and melanoma brain metastases > 2 cm in size treated with MF-SRS (3 x 9 Gy) or surgery + MF-SRS to resection cavity were analyzed. The primary end point of the study was the local control.Results:Between from March 2005 to June 2015, a total of 91 patients (MF-SRS, 46 pts; surgery + MF-SRS, 45 pts) were evaluated in this study. The median survival times were 13.2 months and 16.1 months in MF-SRS and surgery + MF-SRS groups, respectively (p = 0.03) and months. The 6-month and 12-month local control rates were 82% and 63% after MF-SRS and 91% ad 83% after surgery + MF-SRS (p = 0.01), respectively; the 1-year incidence of new distant brain metastases were 53% and 45%, respectively (p = 0.1). Nine patients undergoing surgery + MF-SRS and 4 subjected to MF-SRS experienced brain radionecrosis (p=0.1), as suggested by magnetic resonance imaging (MRI) and (F-DOPA) PET-CT imaging. According to RTOG Common Toxicity Criteria, neurological grade 3 toxicities due to brain radionecrosis was similar between groups (MF-SRS, 2 pts; surgery + MF-SRS, 4 pts). For both groups, the target volume and the volumes of normal brain receiving doses of 18–21 Gy were predictive of radionecrosis.Conclusions:For patients with large resistant brain metastases, surgery plus MF-SRS is an effective treatment modality associated with better local control as compared with MF-SRS alone. These results need to be confirmed in prospective randomized studies." @default.
- W2588136719 created "2017-02-24" @default.
- W2588136719 creator A5080572439 @default.
- W2588136719 date "2016-09-21" @default.
- W2588136719 modified "2023-09-27" @default.
- W2588136719 title "P13.15 Multi-fraction stereotactic radiosurgery (MF-SRS) versus surgery plus MF-SRS for patients with large radioresistant brain metastases" @default.
- W2588136719 doi "https://doi.org/10.1093/neuonc/now188.259" @default.
- W2588136719 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5782752" @default.
- W2588136719 hasPublicationYear "2016" @default.
- W2588136719 type Work @default.
- W2588136719 sameAs 2588136719 @default.
- W2588136719 citedByCount "0" @default.
- W2588136719 crossrefType "journal-article" @default.
- W2588136719 hasAuthorship W2588136719A5080572439 @default.
- W2588136719 hasBestOaLocation W25881367191 @default.
- W2588136719 hasConcept C126838900 @default.
- W2588136719 hasConcept C2780387249 @default.
- W2588136719 hasConcept C2989005 @default.
- W2588136719 hasConcept C509974204 @default.
- W2588136719 hasConcept C58962609 @default.
- W2588136719 hasConcept C71924100 @default.
- W2588136719 hasConceptScore W2588136719C126838900 @default.
- W2588136719 hasConceptScore W2588136719C2780387249 @default.
- W2588136719 hasConceptScore W2588136719C2989005 @default.
- W2588136719 hasConceptScore W2588136719C509974204 @default.
- W2588136719 hasConceptScore W2588136719C58962609 @default.
- W2588136719 hasConceptScore W2588136719C71924100 @default.
- W2588136719 hasIssue "suppl_4" @default.
- W2588136719 hasLocation W25881367191 @default.
- W2588136719 hasLocation W25881367192 @default.
- W2588136719 hasOpenAccess W2588136719 @default.
- W2588136719 hasPrimaryLocation W25881367191 @default.
- W2588136719 hasRelatedWork W118146904 @default.
- W2588136719 hasRelatedWork W1519247148 @default.
- W2588136719 hasRelatedWork W2144161415 @default.
- W2588136719 hasRelatedWork W2168211519 @default.
- W2588136719 hasRelatedWork W2383357592 @default.
- W2588136719 hasRelatedWork W2563463225 @default.
- W2588136719 hasRelatedWork W2997413739 @default.
- W2588136719 hasRelatedWork W3094269541 @default.
- W2588136719 hasRelatedWork W48708379 @default.
- W2588136719 hasRelatedWork W969516745 @default.
- W2588136719 hasVolume "18" @default.
- W2588136719 isParatext "false" @default.
- W2588136719 isRetracted "false" @default.
- W2588136719 magId "2588136719" @default.
- W2588136719 workType "article" @default.