FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588146871> ?p ?o ?g. }

• W2588146871 abstract "Abstract MicroRNAs (miRNAs) play important roles in the fibrosis of systemic sclerosis (SSc). However, the underlying miRNA-mRNA regulatory network is not fully understood. A systemic investigation of the role of miRNAs would be very valuable for increasing our knowledge of the pathogenesis of SSc. Here, we combined miRNA and mRNA expression profiles and bioinformatics analyses and then performed validation experiments. we identified 21 miRNAs and 2698 mRNAs that were differentially expressed in SSc. Among these, 17 miRNAs and their 33 target mRNAs (55 miRNA-mRNA pairs) were involved in Toll-like receptor, transforming growth factor β and Wnt signalling pathways. Validation experiments revealed that miR-146b, miR-130b, miR-21, miR-31 and miR-34a levels were higher whereas miR-145 levels were lower in SSc skin tissues and fibroblasts, normal fibroblasts and endothelial cells that were stimulated with SSc serum. ACVR2B, FZD2, FZD5 and SOX2 levels were increased in SSc skin fibroblasts, normal fibroblasts and endothelial cells that were stimulated with SSc serum. We did not identify any negative correlations among these miRNA-mRNA pairs. miR-21 was specifically expressed at higher levels in SSc serum. Six miRNAs and 4 mRNAs appear to play important roles in the pathogenesis of SSc are worth investigating in future functional studies." @default.
• W2588146871 created "2017-02-24" @default.
• W2588146871 creator A5017351585 @default.
• W2588146871 creator A5044960111 @default.
• W2588146871 creator A5055245395 @default.
• W2588146871 creator A5057035818 @default.
• W2588146871 creator A5069458166 @default.
• W2588146871 creator A5078867858 @default.
• W2588146871 creator A5085248434 @default.
• W2588146871 date "2017-02-17" @default.
• W2588146871 modified "2023-10-01" @default.
• W2588146871 title "Integration of microRNA and mRNA expression profiles in the skin of systemic sclerosis patients" @default.
• W2588146871 cites W1518950845 @default.
• W2588146871 cites W184510336 @default.
• W2588146871 cites W1966498224 @default.
• W2588146871 cites W1968129433 @default.
• W2588146871 cites W1987728581 @default.
• W2588146871 cites W2013888190 @default.
• W2588146871 cites W2015387324 @default.
• W2588146871 cites W2015979702 @default.
• W2588146871 cites W2021328201 @default.
• W2588146871 cites W2021359707 @default.
• W2588146871 cites W2024866056 @default.
• W2588146871 cites W2027258910 @default.
• W2588146871 cites W2034902085 @default.
• W2588146871 cites W2039447393 @default.
• W2588146871 cites W2043946672 @default.
• W2588146871 cites W2055313665 @default.
• W2588146871 cites W2059114286 @default.
• W2588146871 cites W2059357290 @default.
• W2588146871 cites W2068113636 @default.
• W2588146871 cites W2074689365 @default.
• W2588146871 cites W2076665629 @default.
• W2588146871 cites W2077336113 @default.
• W2588146871 cites W2077475358 @default.
• W2588146871 cites W2085289774 @default.
• W2588146871 cites W2102656714 @default.
• W2588146871 cites W2104223556 @default.
• W2588146871 cites W2115093090 @default.
• W2588146871 cites W2121354606 @default.
• W2588146871 cites W2127643187 @default.
• W2588146871 cites W2133465414 @default.
• W2588146871 cites W2134005459 @default.
• W2588146871 cites W2140932664 @default.
• W2588146871 cites W2143145944 @default.
• W2588146871 cites W2146203649 @default.
• W2588146871 cites W2149966907 @default.
• W2588146871 cites W2158217645 @default.
• W2588146871 cites W2160289454 @default.
• W2588146871 cites W2163482204 @default.
• W2588146871 cites W2165160668 @default.
• W2588146871 cites W2233495549 @default.
• W2588146871 cites W2299513640 @default.
• W2588146871 cites W2318370963 @default.
• W2588146871 cites W2419274075 @default.
• W2588146871 cites W2519768493 @default.
• W2588146871 cites W4211149849 @default.
• W2588146871 cites W4233799263 @default.
• W2588146871 doi "https://doi.org/10.1038/srep42899" @default.
• W2588146871 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5314349" @default.
• W2588146871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28211533" @default.
• W2588146871 hasPublicationYear "2017" @default.
• W2588146871 type Work @default.
• W2588146871 sameAs 2588146871 @default.
• W2588146871 citedByCount "35" @default.
• W2588146871 countsByYear W25881468712017 @default.
• W2588146871 countsByYear W25881468712018 @default.
• W2588146871 countsByYear W25881468712019 @default.
• W2588146871 countsByYear W25881468712020 @default.
• W2588146871 countsByYear W25881468712021 @default.
• W2588146871 countsByYear W25881468712022 @default.
• W2588146871 countsByYear W25881468712023 @default.
• W2588146871 crossrefType "journal-article" @default.
• W2588146871 hasAuthorship W2588146871A5017351585 @default.
• W2588146871 hasAuthorship W2588146871A5044960111 @default.
• W2588146871 hasAuthorship W2588146871A5055245395 @default.
• W2588146871 hasAuthorship W2588146871A5057035818 @default.
• W2588146871 hasAuthorship W2588146871A5069458166 @default.
• W2588146871 hasAuthorship W2588146871A5078867858 @default.
• W2588146871 hasAuthorship W2588146871A5085248434 @default.
• W2588146871 hasBestOaLocation W25881468711 @default.
• W2588146871 hasConcept C104317684 @default.
• W2588146871 hasConcept C105580179 @default.
• W2588146871 hasConcept C137620995 @default.
• W2588146871 hasConcept C142724271 @default.
• W2588146871 hasConcept C145059251 @default.
• W2588146871 hasConcept C203014093 @default.
• W2588146871 hasConcept C2780559512 @default.
• W2588146871 hasConcept C2780942790 @default.
• W2588146871 hasConcept C502942594 @default.
• W2588146871 hasConcept C54355233 @default.
• W2588146871 hasConcept C60644358 @default.
• W2588146871 hasConcept C62478195 @default.
• W2588146871 hasConcept C71924100 @default.
• W2588146871 hasConcept C86803240 @default.
• W2588146871 hasConcept C95444343 @default.
• W2588146871 hasConceptScore W2588146871C104317684 @default.
• W2588146871 hasConceptScore W2588146871C105580179 @default.
• W2588146871 hasConceptScore W2588146871C137620995 @default.
• W2588146871 hasConceptScore W2588146871C142724271 @default.

• next