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• W2588176575 startingPage "335" @default.
• W2588176575 abstract "Shigella spp. causing bacterial diarrhea and dysentery are human enteroinvasive bacterial pathogens that are orally transmitted through contaminated food and water and cause bacillary dysentery. Although natural Shigella infections are restricted to humans and primates, several smaller animal models are used to analyze individual steps in pathogenesis. No animal model fully duplicates the human response and sustaining the models requires expensive animals, costly maintenance of animal facilities, veterinary services and approved animal protocols. This study proposes the development of the caterpillar larvae of Galleria mellonella as a simple, inexpensive, informative, and rapid in-vivo model for evaluating virulence and the interaction of Shigella with cells of the insect innate immunity. Virulent Shigella injected through the forelegs causes larvae death. The mortality rates were dependent on the Shigella strain, the infectious dose, and the presence of the virulence plasmid. Wild-type S. flexneri 2a, persisted and replicated within the larvae, resulting in haemocyte cell death, whereas plasmid-cured mutants were rapidly cleared. Histology of the infected larvae in conjunction with fluorescence, immunofluorescence, and transmission electron microscopy indicate that S. flexneri reside within a vacuole of the insect haemocytes that ultrastructurally resembles vacuoles described in studies with mouse and human macrophage cell lines. Some of these bacteria-laden vacuoles had double-membranes characteristic of autophagosomes. These results suggest that G. mellonella larvae can be used as an easy-to-use animal model to understand Shigella pathogenesis that requires none of the time and labor-consuming procedures typical of other systems." @default.
• W2588176575 created "2017-02-24" @default.
• W2588176575 creator A5016701082 @default.
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• W2588176575 date "2017-02-13" @default.
• W2588176575 modified "2023-09-25" @default.
• W2588176575 title "The<i>Galleria mellonella</i>larvae as an<i>in vivo</i>model for evaluation of<i>Shigella</i>virulence" @default.
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• W2588176575 doi "https://doi.org/10.1080/19490976.2017.1293225" @default.
• W2588176575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5570432" @default.
• W2588176575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28277944" @default.

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