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• W2588179990 abstract "OBJECTIVES: To assess recent rates of post-stroke dementia (PSD) and quantify racial disparities in diagnosis of Alzheimer9s Disease (AD) and Non-Alzheimer9s Disease dementia in the US Southeastern region (‘stroke belt buckle’).BACKGROUND: Cerebrovascular disease is the second leading cause of dementia. Blacks are at higher risk for stroke, but racial differences in the incidence of dementia among people with established cerebrovascular disease have not been well studied, especially in the highly stroke-prone southeastern US region.DESIGN/METHODS: Utilizing the South Carolina hospital discharge database, adults (18+) with a primary diagnosis of stroke (ICD9 430-438) from 2000 to 2012 were longitudinally followed post-index stroke with dementia diagnoses identified. Overall prevalence and linear incidence trends of dementia based on index stroke event were assessed by regression analysis stratified by black and white race.RESULTS: Average person-years of follow-up from index stroke event to censor (dementia/death) was 5.06 (SD = 3.57). Among 123,586 index stroke patients, 11.9[percnt] developed dementia (Non-AD 4.6[percnt]; AD 7.3[percnt]) following the stroke event; with 11.7[percnt] among ischemic stroke patients, 9.9[percnt] hemorrhagic stroke patients. Overall, incidence of PSD increased from 2.2 in 2000 to 4.4 per 100 person-years (100PY) in 2012 (p=0.002) (Non-AD 0.9 to 1.9; AD 1.37 to 2.5/100PY). Compared to whites, blacks had higher rates of all-type dementia (12.5[percnt] vs. 11.8[percnt], OR 1.08: 95[percnt] CI 1.04-1.12) and Non-AD dementia (5.9[percnt] vs. 4.2[percnt], OR 1.43: 95[percnt] CI 1.36-1.51), but lower rates of AD dementia (7.6[percnt] vs. 6.7[percnt], OR 0.87: 95[percnt] CI 0.83-0.92).CONCLUSIONS: Over the last decade, incidence of PSD significantly increased in South Carolina. Black stroke patients had higher overall rates of PSD than whites, but this difference was largely driven by a comparatively greater burden of Non-AD dementia. Since Non-AD dementia is predominantly composed of vascular dementia, better vascular risk factor control may help bridge this racial disparity. Disclosure: Dr. Boan has nothing to disclose. Dr. Lackland has nothing to disclose. Dr. Feng has nothing to disclose. Dr. Voeks has nothing to disclose. Dr. Adams has received personal compensation for activities with Reach Call Inc. as an owner and speaker and from Genentech, Novartis, and Boehringer Ingelheim as a speaker. Dr. Bachman has nothing to disclose. Dr. Ovbiagele has nothing to disclose." @default.
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• W2588179990 date "2016-04-05" @default.
• W2588179990 modified "2023-09-25" @default.
• W2588179990 title "Temporal and Racial Trends in Post-Stroke Dementia in the “Stroke Buckle” of the United States (P1.099)" @default.
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