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• W2588189104 abstract "Background.Little is known about preload-dependent cardiac function after brain death (BD) and subsequent graft preservation. Methods. A validated model of BD in rabbits was developed and myocardial performance was studied after BD induction and 1 hour of subsequent global hypothermic ischemia using a validated rabbit model and an isolated work-performing heart preparation. Results.Significant decreases in stroke work, left ventricular contractility, and left ventricular relaxation were obsewed 2 hours after BD. After global hypothermic iachemia, significant decreases in stroke work, left ventricular contractility, and left ventricular relaxation were E arly allograft failure remains a significant problem after orthotropiccardiac transplantathin, occurring in up to 25~0 of patients [1]. This failure may be related to the myocardial changes occurring after brain death in the organ donor. In both clinical and experimental settings, brain death causes major histopathologic and functional changes in the myocardium [2] and is complicated by hemodynamic instability associated with catecholamine fluxes. Novitzky and associates [3] demonstrated an 11fold increase in epinephrine, a threefold increase in norepinephrine, and a twofold increase in serum dopamine concentrations after brain death in the chacma baboon. More recently, Bittner and colleagues [2] demonstrated 800%, 700%, and 100Yoincreases in dopamine, epinephrine, and norepinephrine levels 15 minutes after brain death using a validated canine model. This “catecholamine storm” leads to calcium overflow injury, causing decreased myocardial conduction, increased coronary artery resistance, and inhibition of myocardial contractile mechanisms [4]. Myocardial damage during brain death results in contraction band necrosis, coagulation necrosis, and myocytolysis [4] and maybe further compounded with global hypothermic ischemia at the time of organ harvest. Bittner and colleagues [2] have demonstrated 30?’. and 25~0decreases in right ventricular and left ventricular function, respectively, 4 hours after brain death in vivo [2]. Four hours of additional hypothermic graft presewation resulted in a further signifi" @default.
• W2588189104 created "2017-02-24" @default.
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• W2588189104 date "1996-01-01" @default.
• W2588189104 modified "2023-09-23" @default.
• W2588189104 title "Death Further Promotes Ischemic ReperfusionInjury of the Rabbit Myocardium" @default.
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