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- W2588211335 abstract "First introduced in the second half of the 19th century, enteric coatings are commonly used to protect acid-labile drugs, reduce the risk of gastric side effects due to irritating drugs, or for local drug delivery to the lower gastrointestinal (GI) tract. The currently available enteric-coatings are based on pH-sensitive weakly acidic polymers. Despite the long history of their use, the causes behind their performance often being unpredictable have not been properly investigated with most of the attention being focused only on the gastric emptying. However, little attention has been given to the postgastric emptying disintegration and dissolution of these dosage forms. This lack of attention has contributed to the difficulty in predicting the in vivo behavior of these dosage forms and to cases of bioavailability problems with some enteric-coated products. Therefore, increased attention needs to be given to this issue." @default.
- W2588211335 created "2017-02-24" @default.
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- W2588211335 date "2017-02-28" @default.
- W2588211335 modified "2023-09-30" @default.
- W2588211335 title "Unpredictable Performance of pH-Dependent Coatings Accentuates the Need for Improved Predictive <i>in Vitro</i> Test Systems" @default.
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- W2588211335 doi "https://doi.org/10.1021/acs.molpharmaceut.6b00877" @default.
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