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- W2588212781 endingPage "a025494" @default.
- W2588212781 startingPage "a025494" @default.
- W2588212781 abstract "Plasmodium falciparum and Plasmodium vivax account for most of the mortality and morbidity associated with malaria in humans. Research and control efforts have focused on infections caused by P. falciparum and P. vivax, but have neglected other malaria parasite species that infect humans. Additionally, many related malaria parasite species infect nonhuman primates (NHPs), and have the potential for transmission to humans. For malaria elimination, the varied and specific challenges of all of these Plasmodium species will need to be considered. Recent advances in molecular genetics and genomics have increased our knowledge of the prevalence and existing diversity of the human and NHP Plasmodium species. We are beginning to identify the extent of the reservoirs of each parasite species in humans and NHPs, revealing their origins as well as potential for adaptation in humans. Here, we focus on the red blood cell stage of human infection and the host cell tropism of each human Plasmodium species. Determinants of tropism are unique among malaria parasite species, presenting a complex challenge for malaria elimination." @default.
- W2588212781 created "2017-02-24" @default.
- W2588212781 creator A5001982224 @default.
- W2588212781 creator A5005592645 @default.
- W2588212781 creator A5038809302 @default.
- W2588212781 creator A5057411925 @default.
- W2588212781 date "2017-02-17" @default.
- W2588212781 modified "2023-09-30" @default.
- W2588212781 title "Host Cell Tropism and Adaptation of Blood-Stage Malaria Parasites: Challenges for Malaria Elimination" @default.
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