FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588365713> ?p ?o ?g. }

• W2588365713 endingPage "169" @default.
• W2588365713 startingPage "161" @default.
• W2588365713 abstract "Purpose of review There are many reports of human variants in proprotein convertase subtilisin–kexin type 9 ( PCSK9 ) that are either gain-of-function (GOF) or loss-of-function (LOF), with downstream effects on LDL cholesterol and cardiovascular disease (CVD) risk. However, data on particular mechanisms have only been minimally curated. Recent findings GOF variants are individually ultrarare, affect all domains of the protein, act to reduce LDL receptor expression through several mechanisms, are a minor cause of familial hypercholesterolemia, have been reported mainly within families, have variable LDL cholesterol–raising effects, and are associated with increased CVD risk mainly through observational studies in families and small cohorts. In contrast, LOF variants can be either ultrarare mutations or relatively more common polymorphisms seen in populations, affect all domains of the protein, act to increase LDL receptor expression through several mechanisms, have variable LDL cholesterol–lowering effects, and have been associated with decreased CVD risk mainly through Mendelian randomization studies in epidemiologic populations. Summary There is considerable complexity underlying the clinical concept of both LOF and GOF variants of PCSK9 . But despite the underlying mechanistic heterogeneity, altered PCSK9 secretion or function is ultimately correlated with plasma LDL cholesterol level, which is also the driver of CVD outcomes." @default.
• W2588365713 created "2017-02-24" @default.
• W2588365713 creator A5035358062 @default.
• W2588365713 creator A5044083268 @default.
• W2588365713 date "2017-04-01" @default.
• W2588365713 modified "2023-10-18" @default.
• W2588365713 title "Complexity of mechanisms among human proprotein convertase subtilisin–kexin type 9 variants" @default.
• W2588365713 cites W1503639662 @default.
• W2588365713 cites W1888435097 @default.
• W2588365713 cites W1923289550 @default.
• W2588365713 cites W1964279010 @default.
• W2588365713 cites W1974078996 @default.
• W2588365713 cites W1980786839 @default.
• W2588365713 cites W1985904950 @default.
• W2588365713 cites W2004032902 @default.
• W2588365713 cites W2011294766 @default.
• W2588365713 cites W2011484220 @default.
• W2588365713 cites W2019076761 @default.
• W2588365713 cites W2023283451 @default.
• W2588365713 cites W2023991608 @default.
• W2588365713 cites W2024110748 @default.
• W2588365713 cites W2025946759 @default.
• W2588365713 cites W2026136832 @default.
• W2588365713 cites W2028682402 @default.
• W2588365713 cites W2040612932 @default.
• W2588365713 cites W2045791858 @default.
• W2588365713 cites W2046707901 @default.
• W2588365713 cites W2050838276 @default.
• W2588365713 cites W2055571770 @default.
• W2588365713 cites W2064207731 @default.
• W2588365713 cites W2064994526 @default.
• W2588365713 cites W2067539811 @default.
• W2588365713 cites W2076648603 @default.
• W2588365713 cites W2078669364 @default.
• W2588365713 cites W2081242409 @default.
• W2588365713 cites W2085677096 @default.
• W2588365713 cites W2099136586 @default.
• W2588365713 cites W2099654648 @default.
• W2588365713 cites W2101979622 @default.
• W2588365713 cites W2112247075 @default.
• W2588365713 cites W2118868005 @default.
• W2588365713 cites W2122864632 @default.
• W2588365713 cites W2127445212 @default.
• W2588365713 cites W2130626257 @default.
• W2588365713 cites W2140622082 @default.
• W2588365713 cites W2153159453 @default.
• W2588365713 cites W2160842595 @default.
• W2588365713 cites W2162101941 @default.
• W2588365713 cites W2163488353 @default.
• W2588365713 cites W2164409290 @default.
• W2588365713 cites W2165624352 @default.
• W2588365713 cites W2191078666 @default.
• W2588365713 cites W2523564199 @default.
• W2588365713 cites W2560062929 @default.
• W2588365713 cites W2802869499 @default.
• W2588365713 doi "https://doi.org/10.1097/mol.0000000000000386" @default.
• W2588365713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28157721" @default.
• W2588365713 hasPublicationYear "2017" @default.
• W2588365713 type Work @default.
• W2588365713 sameAs 2588365713 @default.
• W2588365713 citedByCount "58" @default.
• W2588365713 countsByYear W25883657132016 @default.
• W2588365713 countsByYear W25883657132017 @default.
• W2588365713 countsByYear W25883657132018 @default.
• W2588365713 countsByYear W25883657132019 @default.
• W2588365713 countsByYear W25883657132020 @default.
• W2588365713 countsByYear W25883657132021 @default.
• W2588365713 countsByYear W25883657132022 @default.
• W2588365713 countsByYear W25883657132023 @default.
• W2588365713 crossrefType "journal-article" @default.
• W2588365713 hasAuthorship W2588365713A5035358062 @default.
• W2588365713 hasAuthorship W2588365713A5044083268 @default.
• W2588365713 hasConcept C104317684 @default.
• W2588365713 hasConcept C105951970 @default.
• W2588365713 hasConcept C126322002 @default.
• W2588365713 hasConcept C127716648 @default.
• W2588365713 hasConcept C134018914 @default.
• W2588365713 hasConcept C135763542 @default.
• W2588365713 hasConcept C181199279 @default.
• W2588365713 hasConcept C2778163477 @default.
• W2588365713 hasConcept C2778824825 @default.
• W2588365713 hasConcept C2778849439 @default.
• W2588365713 hasConcept C2779134260 @default.
• W2588365713 hasConcept C2779811187 @default.
• W2588365713 hasConcept C2779901538 @default.
• W2588365713 hasConcept C2780072125 @default.
• W2588365713 hasConcept C2780948078 @default.
• W2588365713 hasConcept C2993967602 @default.
• W2588365713 hasConcept C43554185 @default.
• W2588365713 hasConcept C54355233 @default.
• W2588365713 hasConcept C55493867 @default.
• W2588365713 hasConcept C60644358 @default.
• W2588365713 hasConcept C71924100 @default.
• W2588365713 hasConcept C86803240 @default.
• W2588365713 hasConceptScore W2588365713C104317684 @default.
• W2588365713 hasConceptScore W2588365713C105951970 @default.
• W2588365713 hasConceptScore W2588365713C126322002 @default.
• W2588365713 hasConceptScore W2588365713C127716648 @default.

• next