FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588392568> ?p ?o ?g. }

• W2588392568 abstract "Abstract Abstract 4128 Background: Although autologous stem-cell transplantation (auto-HCT) is sporadically used in patients with Waldenström macroglobulinemia (WM), hematopoietic stem cells (HSC) are routinely collected and cryopreserved at many transplant centers after initial cytoreduction, prior to the use of myelotoxic agents like cladribine. The aim of this study is to evaluate the number of patients who underwent HSC collection, the adequacy of collection and the number of patients who eventually received auto-HCT. Methods: We performed a retrospective chart review for 431 adult patients with WM who were seen at the University Of Texas-MD Anderson Cancer Center (MDACC). Fifty-five patients (12.8%) underwent HSC collection. Our analyses were focused on these 55 patients. Results: A total of 431 patients with WM were seen at our institution between 1978 and 2010. One-hundred and seven (24.8%) of these patients were referred to the Department of Stem cell Transplantation (SCT). Fifty-two patients either continued conventional therapy (31) or received plasmapheresis for hyperviscosity (21). Fifty-five (12.8%) patients underwent HSC collection either through peripheral blood (PB) HSC mobilization or bone marrow (BM) harvest. Characteristics of the 55 patients undergoing HSC collection are summarized Table 1. In 2 patients, HSC were collected by BM harvest only. Fifty-three patients underwent PB HSC mobilization with either growth factors only (34) that included filgrastim, pegfilgrastim or plerixafor; or with growth factors plus chemotherapy (19) that included cyclophosphamide alone or in combination with vincristine, doxorubicin and dexamethasone (CVAD). Out of 53 patients undergoing PBHSC mobilization, 2 patients failed to mobilize any HSC despite growth factors and chemotherapy, while 2 additional patients had inadequate HSC collection (< 2 × 10e6 CD34+ cells/kg). Forty-nine of the 53 patients undergoing PBHSC mobilization had adequate HSC collection (> 2 × 10e6 CD34 cells/kg). Overall, 51 patients (PBHSC: 49, BM harvest: 2, 93%) had an adequate (> 2 × 10e 6 CD34/kg) HSC collection. The median HSC dose collected from these patients was 6.9 × 10e6/kg ((0.5–24.1) after a median of 3 collections (1 to 7). Fifteen patients had received cladribine prior to HSC collection, and 14 (93%) of them had adequate HSC collection. However, 7/15 patients (47%) with prior cladribine required chemomobilization, in contrast to 11/39 (28%) without prior cladribine (p=0.21). In 34/51 patients with adequate collection, HSC were cryopreserved for use at the time of relapse. Thus far, 3/34 (8.8%) have gone on to receive auto-HCT after 12, 27.3 and 45.2 months, respectively. In 31/34 (91%) patients, HSC have been cryopreserved for a median duration of 24.6 months (3.1 to 187.6 months). In 17 patients, HSC were collected with the intention to immediately proceed to auto-HCT, and these patients proceeded to HDM and auto-HCT within 3 months of HSC collection (range being 0.1–2.7 months). Forty-four patients are alive after a median of 37.5 months (2.4 to 187.6) from HSC collection. Kaplan-Meier estimate of 5-year overall survival for all patients from HSC collection was 76%. Conclusions: Current frontline regimens for WM are associated with high overall response rates (66–94%); however, complete remission (CR) rates (4–7%) remain low. Given the feasibility of HSC collection in patients with WM, earlier incorporation of auto-HCT for younger patients could be studied as a means of improving CR rates, and perhaps thereby improving both remission duration and overall survival. Disclosures: No relevant conflicts of interest to declare." @default.
• W2588392568 created "2017-02-24" @default.
• W2588392568 creator A5008785159 @default.
• W2588392568 creator A5015342719 @default.
• W2588392568 creator A5026422612 @default.
• W2588392568 creator A5047673513 @default.
• W2588392568 creator A5048913229 @default.
• W2588392568 creator A5050962913 @default.
• W2588392568 creator A5053904944 @default.
• W2588392568 creator A5055929208 @default.
• W2588392568 creator A5060313982 @default.
• W2588392568 creator A5061435647 @default.
• W2588392568 creator A5066894053 @default.
• W2588392568 creator A5068834306 @default.
• W2588392568 date "2012-11-16" @default.
• W2588392568 modified "2023-09-29" @default.
• W2588392568 title "Feasibility of Hematopoietic Stem Cell Collection and Cryopreservation in Waldenstrom's Macroglobulinemia" @default.
• W2588392568 doi "https://doi.org/10.1182/blood.v120.21.4128.4128" @default.
• W2588392568 hasPublicationYear "2012" @default.
• W2588392568 type Work @default.
• W2588392568 sameAs 2588392568 @default.
• W2588392568 citedByCount "0" @default.
• W2588392568 crossrefType "journal-article" @default.
• W2588392568 hasAuthorship W2588392568A5008785159 @default.
• W2588392568 hasAuthorship W2588392568A5015342719 @default.
• W2588392568 hasAuthorship W2588392568A5026422612 @default.
• W2588392568 hasAuthorship W2588392568A5047673513 @default.
• W2588392568 hasAuthorship W2588392568A5048913229 @default.
• W2588392568 hasAuthorship W2588392568A5050962913 @default.
• W2588392568 hasAuthorship W2588392568A5053904944 @default.
• W2588392568 hasAuthorship W2588392568A5055929208 @default.
• W2588392568 hasAuthorship W2588392568A5060313982 @default.
• W2588392568 hasAuthorship W2588392568A5061435647 @default.
• W2588392568 hasAuthorship W2588392568A5066894053 @default.
• W2588392568 hasAuthorship W2588392568A5068834306 @default.
• W2588392568 hasConcept C109159458 @default.
• W2588392568 hasConcept C179933525 @default.
• W2588392568 hasConcept C196843134 @default.
• W2588392568 hasConcept C203014093 @default.
• W2588392568 hasConcept C2776364478 @default.
• W2588392568 hasConcept C2776391228 @default.
• W2588392568 hasConcept C2777408962 @default.
• W2588392568 hasConcept C2779338263 @default.
• W2588392568 hasConcept C2781038049 @default.
• W2588392568 hasConcept C28328180 @default.
• W2588392568 hasConcept C54355233 @default.
• W2588392568 hasConcept C71924100 @default.
• W2588392568 hasConcept C86803240 @default.
• W2588392568 hasConceptScore W2588392568C109159458 @default.
• W2588392568 hasConceptScore W2588392568C179933525 @default.
• W2588392568 hasConceptScore W2588392568C196843134 @default.
• W2588392568 hasConceptScore W2588392568C203014093 @default.
• W2588392568 hasConceptScore W2588392568C2776364478 @default.
• W2588392568 hasConceptScore W2588392568C2776391228 @default.
• W2588392568 hasConceptScore W2588392568C2777408962 @default.
• W2588392568 hasConceptScore W2588392568C2779338263 @default.
• W2588392568 hasConceptScore W2588392568C2781038049 @default.
• W2588392568 hasConceptScore W2588392568C28328180 @default.
• W2588392568 hasConceptScore W2588392568C54355233 @default.
• W2588392568 hasConceptScore W2588392568C71924100 @default.
• W2588392568 hasConceptScore W2588392568C86803240 @default.
• W2588392568 hasLocation W25883925681 @default.
• W2588392568 hasOpenAccess W2588392568 @default.
• W2588392568 hasPrimaryLocation W25883925681 @default.
• W2588392568 hasRelatedWork W1585805784 @default.
• W2588392568 hasRelatedWork W2007757074 @default.
• W2588392568 hasRelatedWork W2165996752 @default.
• W2588392568 hasRelatedWork W2259033287 @default.
• W2588392568 hasRelatedWork W2523973098 @default.
• W2588392568 hasRelatedWork W2524429514 @default.
• W2588392568 hasRelatedWork W2550520213 @default.
• W2588392568 hasRelatedWork W2553775977 @default.
• W2588392568 hasRelatedWork W2557567323 @default.
• W2588392568 hasRelatedWork W2558387528 @default.
• W2588392568 hasRelatedWork W2559083552 @default.
• W2588392568 hasRelatedWork W2563902799 @default.
• W2588392568 hasRelatedWork W2576693729 @default.
• W2588392568 hasRelatedWork W2586257385 @default.
• W2588392568 hasRelatedWork W2596944353 @default.
• W2588392568 hasRelatedWork W2970424211 @default.
• W2588392568 hasRelatedWork W2979378351 @default.
• W2588392568 hasRelatedWork W2979391391 @default.
• W2588392568 hasRelatedWork W3094893553 @default.
• W2588392568 hasRelatedWork W3111573605 @default.
• W2588392568 isParatext "false" @default.
• W2588392568 isRetracted "false" @default.
• W2588392568 magId "2588392568" @default.
• W2588392568 workType "article" @default.