FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588405611> ?p ?o ?g. }

• W2588405611 endingPage "98" @default.
• W2588405611 startingPage "85" @default.
• W2588405611 abstract "The present review describes available evidence about the fate of micronuclei and micronucleated cells. Micronuclei are small, extranuclear chromatin bodies surrounded by a nuclear envelope. The mechanisms underlying the formation of micronuclei are well understood but not much is known about the potential fate of micronuclei and micronucleated cells. Many studies with different experimental approaches addressed the various aspects of the post-mitotic fate of micronuclei and micronucleated cells. These studies are reviewed here considering four basic possibilities for potential fates of micronuclei: degradation of the micronucleus or the micronucleated cell, reincorporation into the main nucleus, extrusion from the cell, and persistence in the cytoplasm. Two additional fates need to be considered: premature chromosome condensation/chromothripsis and the elimination of micronucleated cells by apoptosis, yielding six potential fates for micronuclei and/or micronucleated cells. The available data is still limited, but it can be concluded that degradation and extrusion of micronuclei might occur in rare cases under specific conditions, reincorporation during the next mitosis occurs more frequently, and the majority of the micronuclei persist without alteration at least until the next mitosis, possibly much longer. Overall, the consequences of micronucleus formation on the cellular level are still far from clear, but they should be investigated further because micronucleus formation may contribute to the initial and later steps of malignant cell transformation, by causing gain or loss of genetic material in the daughter cells and by the possibility of massive chromosome rearrangement in chromosomes entrapped within a micronucleus by the mechanisms of chromothripsis and chromoanagenesis." @default.
• W2588405611 created "2017-02-24" @default.
• W2588405611 creator A5002204564 @default.
• W2588405611 creator A5014325801 @default.
• W2588405611 creator A5025374231 @default.
• W2588405611 creator A5031309598 @default.
• W2588405611 creator A5075189337 @default.
• W2588405611 creator A5079721683 @default.
• W2588405611 date "2017-01-01" @default.
• W2588405611 modified "2023-10-13" @default.
• W2588405611 title "Fate of micronuclei and micronucleated cells" @default.
• W2588405611 cites W1600873259 @default.
• W2588405611 cites W1601755300 @default.
• W2588405611 cites W1906506906 @default.
• W2588405611 cites W1936017830 @default.
• W2588405611 cites W1966396572 @default.
• W2588405611 cites W1967250409 @default.
• W2588405611 cites W1970836866 @default.
• W2588405611 cites W1974549850 @default.
• W2588405611 cites W1977016073 @default.
• W2588405611 cites W1978556663 @default.
• W2588405611 cites W1981675989 @default.
• W2588405611 cites W1984169555 @default.
• W2588405611 cites W1985321972 @default.
• W2588405611 cites W1986142424 @default.
• W2588405611 cites W1986303971 @default.
• W2588405611 cites W1988756673 @default.
• W2588405611 cites W1989951043 @default.
• W2588405611 cites W1992795418 @default.
• W2588405611 cites W1993940772 @default.
• W2588405611 cites W1995423367 @default.
• W2588405611 cites W2005523263 @default.
• W2588405611 cites W2006127670 @default.
• W2588405611 cites W2008685892 @default.
• W2588405611 cites W2013455195 @default.
• W2588405611 cites W2015236057 @default.
• W2588405611 cites W2015432866 @default.
• W2588405611 cites W2015494582 @default.
• W2588405611 cites W2019179449 @default.
• W2588405611 cites W2019315570 @default.
• W2588405611 cites W2021569333 @default.
• W2588405611 cites W2024889754 @default.
• W2588405611 cites W2039152070 @default.
• W2588405611 cites W2042107535 @default.
• W2588405611 cites W2043717986 @default.
• W2588405611 cites W2045762186 @default.
• W2588405611 cites W2046255677 @default.
• W2588405611 cites W2049803653 @default.
• W2588405611 cites W2050896501 @default.
• W2588405611 cites W2052729815 @default.
• W2588405611 cites W2053493344 @default.
• W2588405611 cites W2057310825 @default.
• W2588405611 cites W2066150390 @default.
• W2588405611 cites W2066883747 @default.
• W2588405611 cites W2068290381 @default.
• W2588405611 cites W2069146956 @default.
• W2588405611 cites W2071969196 @default.
• W2588405611 cites W2076823292 @default.
• W2588405611 cites W2077145482 @default.
• W2588405611 cites W2083797876 @default.
• W2588405611 cites W2087237423 @default.
• W2588405611 cites W2089671649 @default.
• W2588405611 cites W2091426884 @default.
• W2588405611 cites W2095617425 @default.
• W2588405611 cites W2103040337 @default.
• W2588405611 cites W2104154956 @default.
• W2588405611 cites W2112784018 @default.
• W2588405611 cites W2114885607 @default.
• W2588405611 cites W2116541338 @default.
• W2588405611 cites W2120321636 @default.
• W2588405611 cites W2121090280 @default.
• W2588405611 cites W2124919647 @default.
• W2588405611 cites W2125984350 @default.
• W2588405611 cites W2127594521 @default.
• W2588405611 cites W2130425672 @default.
• W2588405611 cites W2131028776 @default.
• W2588405611 cites W2135310333 @default.
• W2588405611 cites W2139234011 @default.
• W2588405611 cites W2139812988 @default.
• W2588405611 cites W2147286842 @default.
• W2588405611 cites W2149312363 @default.
• W2588405611 cites W2153980143 @default.
• W2588405611 cites W2154067349 @default.
• W2588405611 cites W2154582697 @default.
• W2588405611 cites W2156760055 @default.
• W2588405611 cites W2156928776 @default.
• W2588405611 cites W2157238336 @default.
• W2588405611 cites W2158723622 @default.
• W2588405611 cites W2158805945 @default.
• W2588405611 cites W2160689867 @default.
• W2588405611 cites W2161799979 @default.
• W2588405611 cites W2274022156 @default.
• W2588405611 cites W2284164251 @default.
• W2588405611 cites W4300769704 @default.
• W2588405611 cites W788755214 @default.
• W2588405611 doi "https://doi.org/10.1016/j.mrrev.2017.02.002" @default.
• W2588405611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28342454" @default.
• W2588405611 hasPublicationYear "2017" @default.

• next