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- W2588426309 abstract "Background Development of hypocalcemia after treatment of hyperparathyroidism results in increased costs and risk of poorer outcomes. Previous studies have shown conflicting data about predictors of hypocalcemia after these procedures. Hypothesis/Objectives The objective of this study was to investigate whether ionized calcium ( iC a) concentrations before treatment are predictive of hypocalcemia or its clinical signs after surgical removal or heat ablation in dogs with primary hyperparathyroidism. Animals Fifty‐four dogs with primary hyperparathyroidism (29 female, 25 male; 49 retrospective, 5 prospective). Methods Dogs were enrolled if they met the inclusion criteria: persistent hypercalcemia ( iC a >1.41 mmol/L) due to primary hyperparathyroidism and absence of preemptive calcitriol treatment. All dogs were treated with parathyroidectomy (n = 37) or percutaneous ultrasound‐guided heat ablation (n = 17). After treatment, iC a was monitored twice daily until plateau or intervention. Results There was a moderate correlation between before‐treatment hypercalcemia and after‐treatment hypocalcemia. The prospective study was terminated due to ethical concerns given findings in the retrospective section. All dogs were placed into groups according to their pretreatment iC a: 1.46–1.61 mmol/L, 1.62–1.71 mmol/L, iC a 1.72–1.81 mmol/L, or >1.81 mmol/L. After treatment, the mean lowest iC a for each group, respectively, was 1.19, 1.18, 1.13, and 1.01 mmol/L. There was a significant association between higher group and proportion of dogs with iC a <1.00 mmol/L ( P = .014). Conclusions and Clinical Importance This study demonstrates a moderate correlation between iC a concentration before treatment and hypocalcemia after treatment. Dogs with higher initial iC a concentrations should be treated to prevent rapid decline and development of clinical hypocalcemia." @default.
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- W2588426309 date "2017-02-18" @default.
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- W2588426309 title "Association of Hypercalcemia Before Treatment With Hypocalcemia After Treatment in Dogs With Primary Hyperparathyroidism" @default.
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- W2588426309 doi "https://doi.org/10.1111/jvim.14644" @default.
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