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• W2588441232 abstract "Anthracyclines, such as doxorubicin, are effective anticancer drugs composed of a tetracyclic polyketide aglycone and one or more deoxysugar moieties, which play a critical role in their biological activity. A facile one-pot combinatorial biosynthetic system was developed for the generation of a range of glycosylated derivatives of anthracyclines. Cocultivation of Streptomyces venezuelae mutants producing two anthracycline aglycones with eight different nucleotide deoxysugar-producing S. venezuelae mutants that coexpress a substrate-flexible glycosyltransferase led to the generation of 16 aklavinone or ε-rhodomycinone glycosides containing diverse deoxysugar moieties, seven of which are new. This demonstrates the potential of the one-pot combinatorial biosynthetic system based on cocultivation as a facile biological tool capable of combining diverse aglycones and deoxysugars to generate structurally diverse polyketides carrying engineered sugars for drug discovery and development." @default.
• W2588441232 created "2017-02-24" @default.
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• W2588441232 date "2017-02-22" @default.
• W2588441232 modified "2023-10-14" @default.
• W2588441232 title "One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of <i>Streptomyces</i> Strains Producing Aglycones and Nucleotide Deoxysugars" @default.
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• W2588441232 doi "https://doi.org/10.1021/acscombsci.6b00194" @default.
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