Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588579781> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2588579781 abstract "Diarrhea is one of the main symptoms of Crohn's disease (CD). It is usually significantly improved with specific CD treatments, loperamide or cholestyramine. However, in some cases, diarrhea becomes refractory. The aim of this study was to assess the safety and efficacy of octreotide in this situation.Fifteen patients with CD refractory diarrhea defined by at least an average of five smooth or liquid stools per day despite an optimized CD treatment were included from three Belgian centers. Two patients were lost to follow-up. A subcutaneous injection of 100 μg octreotide was performed three times a day during three days. When the drug had been well tolerated, an intramuscular injection of 30 mg octreotide (Sandostatin® LAR 30) was realized. Evaluation was done at day 31. The primary endpoint was to assess the effect on the mean number of smooth or liquid stools per day.A significant reduction (p = 0.0001) of the average number of smooth or liquid stools over the last seven days was observed between baseline and day 31. The maximum number of smooth or liquid stools also significantly decreased (p = 0.0009). Four patients (26.7%) presented mild nonspecific adverse events but no serious one. We also observed a significant decrease (p = 0.0006) of the Harvey-Bradshaw Index (HBI) and a significant improvement (p = 0.0012) of the inflammatory bowel disease questionnaire (IBDQ).In this uncontrolled open-label study, octreotide appeared safe and effective in CD refractory diarrhea, in addition to CD treatments. It significantly improved the number of liquid or smooth stools, the HBI and the IBDQ." @default.
- W2588579781 created "2017-02-24" @default.
- W2588579781 creator A5027139545 @default.
- W2588579781 creator A5032927697 @default.
- W2588579781 creator A5044099435 @default.
- W2588579781 creator A5054109827 @default.
- W2588579781 creator A5065356435 @default.
- W2588579781 creator A5089342987 @default.
- W2588579781 date "2017-02-13" @default.
- W2588579781 modified "2023-09-24" @default.
- W2588579781 title "Evaluation of the efficacy of octreotide LAR in the treatment of Crohn’s disease associated refractory diarrhea" @default.
- W2588579781 cites W1589696729 @default.
- W2588579781 cites W1641318086 @default.
- W2588579781 cites W1671682816 @default.
- W2588579781 cites W1791292815 @default.
- W2588579781 cites W1971726757 @default.
- W2588579781 cites W1988604248 @default.
- W2588579781 cites W1995287860 @default.
- W2588579781 cites W2022661087 @default.
- W2588579781 cites W2033081617 @default.
- W2588579781 cites W2043413148 @default.
- W2588579781 cites W2046549547 @default.
- W2588579781 cites W2057468394 @default.
- W2588579781 cites W2065637841 @default.
- W2588579781 cites W2085380131 @default.
- W2588579781 cites W2137275477 @default.
- W2588579781 cites W2144627584 @default.
- W2588579781 cites W2161723853 @default.
- W2588579781 cites W2161740442 @default.
- W2588579781 cites W3149527659 @default.
- W2588579781 doi "https://doi.org/10.1080/00365521.2017.1284893" @default.
- W2588579781 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28270045" @default.
- W2588579781 hasPublicationYear "2017" @default.
- W2588579781 type Work @default.
- W2588579781 sameAs 2588579781 @default.
- W2588579781 citedByCount "6" @default.
- W2588579781 countsByYear W25885797812017 @default.
- W2588579781 countsByYear W25885797812018 @default.
- W2588579781 countsByYear W25885797812019 @default.
- W2588579781 countsByYear W25885797812021 @default.
- W2588579781 countsByYear W25885797812022 @default.
- W2588579781 crossrefType "journal-article" @default.
- W2588579781 hasAuthorship W2588579781A5027139545 @default.
- W2588579781 hasAuthorship W2588579781A5032927697 @default.
- W2588579781 hasAuthorship W2588579781A5044099435 @default.
- W2588579781 hasAuthorship W2588579781A5054109827 @default.
- W2588579781 hasAuthorship W2588579781A5065356435 @default.
- W2588579781 hasAuthorship W2588579781A5089342987 @default.
- W2588579781 hasBestOaLocation W25885797812 @default.
- W2588579781 hasConcept C121332964 @default.
- W2588579781 hasConcept C126322002 @default.
- W2588579781 hasConcept C142424586 @default.
- W2588579781 hasConcept C197934379 @default.
- W2588579781 hasConcept C2776297358 @default.
- W2588579781 hasConcept C2777573665 @default.
- W2588579781 hasConcept C2779134260 @default.
- W2588579781 hasConcept C2779280984 @default.
- W2588579781 hasConcept C2779802037 @default.
- W2588579781 hasConcept C2781025020 @default.
- W2588579781 hasConcept C71924100 @default.
- W2588579781 hasConcept C87355193 @default.
- W2588579781 hasConcept C90924648 @default.
- W2588579781 hasConceptScore W2588579781C121332964 @default.
- W2588579781 hasConceptScore W2588579781C126322002 @default.
- W2588579781 hasConceptScore W2588579781C142424586 @default.
- W2588579781 hasConceptScore W2588579781C197934379 @default.
- W2588579781 hasConceptScore W2588579781C2776297358 @default.
- W2588579781 hasConceptScore W2588579781C2777573665 @default.
- W2588579781 hasConceptScore W2588579781C2779134260 @default.
- W2588579781 hasConceptScore W2588579781C2779280984 @default.
- W2588579781 hasConceptScore W2588579781C2779802037 @default.
- W2588579781 hasConceptScore W2588579781C2781025020 @default.
- W2588579781 hasConceptScore W2588579781C71924100 @default.
- W2588579781 hasConceptScore W2588579781C87355193 @default.
- W2588579781 hasConceptScore W2588579781C90924648 @default.
- W2588579781 hasFunder F4320307778 @default.
- W2588579781 hasFunder F4320310389 @default.
- W2588579781 hasLocation W25885797811 @default.
- W2588579781 hasLocation W25885797812 @default.
- W2588579781 hasLocation W25885797813 @default.
- W2588579781 hasOpenAccess W2588579781 @default.
- W2588579781 hasPrimaryLocation W25885797811 @default.
- W2588579781 hasRelatedWork W1026634730 @default.
- W2588579781 hasRelatedWork W120732878 @default.
- W2588579781 hasRelatedWork W162882544 @default.
- W2588579781 hasRelatedWork W1997014660 @default.
- W2588579781 hasRelatedWork W2038765960 @default.
- W2588579781 hasRelatedWork W2066556367 @default.
- W2588579781 hasRelatedWork W2350204259 @default.
- W2588579781 hasRelatedWork W2382325019 @default.
- W2588579781 hasRelatedWork W2588579781 @default.
- W2588579781 hasRelatedWork W2132864153 @default.
- W2588579781 isParatext "false" @default.
- W2588579781 isRetracted "false" @default.
- W2588579781 magId "2588579781" @default.
- W2588579781 workType "article" @default.