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- W2588587101 abstract "Agerelated changes in the number of leucocytes and other cells of bone marrow origin were investigated in human dermis. The total number of CD45� positive cells increased with age, while the amount of fibroblasts in the dermis gradually decreased. Additionally, an agerelated decrease in the number of PCNApositive fibroblastlike cells, which indicates thei r proliferative activity, was clearly shown. The cor� relation analysis revealed that the ageassociated increase in the amount of CD45�positive cells is statistically related to a decrease in the total number of PCNAposit ive fibroblastlike cells in the dermis. Therefore, the accumulation of CD45�positive cells in the human dermi s with age may well be regarded as a mechanism that initiates an inflammatory response and is responsible for the emergence of signs of aging. It is also possible that an increased number of bone marrowderived cells in the dermis, which are accumulated with age, has an effect on the agerelated decrease in the amount of fibroblasts in the dermis." @default.
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- W2588587101 date "2013-01-01" @default.
- W2588587101 modified "2023-09-26" @default.
- W2588587101 title "AgeRelated Changes in Number of CD45Positive Cells in Human Dermis" @default.
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