FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588607672> ?p ?o ?g. }

• W2588607672 endingPage "2848" @default.
• W2588607672 startingPage "2834" @default.
• W2588607672 abstract "Photoreceptor-specific transcription of individual genes collectively constitutes the transcriptional profile that orchestrates the structural and functional characteristics of each photoreceptor type. It is challenging, however, to study the transcriptional specificity of individual photoreceptor genes because each gene's distinct spatiotemporal transcription patterns are determined by the unique interactions between a specific set of transcription factors and the gene's own cis- regulatory elements (CREs), which remain unknown for most of the genes. For example, it is unknown what CREs underlie the zebrafish mpp5b ponli ( ponli ) and crumbs2b ( crb2b ) apical polarity genes' restrictive transcription in the red, green, and blue (RGB) cones in the retina, but not in other retinal cell types. Here we show that the intronic enhancers of both the ponli and crb2b genes are conserved among teleost species and that they share sequence motifs that are critical for RGB cone-specific transcription. Given their similarities in sequences and functions, we name the ponli and crb2b enhancers collectively rainbow enhancers. Rainbow enhancers may represent a cis- regulatory mechanism to turn on a group of genes that are commonly and restrictively expressed in RGB cones, which largely define the beginning of the color vision pathway. SIGNIFICANCE STATEMENT Dim-light achromatic vision and bright-light color vision are initiated in rod and several types of cone photoreceptors, respectively; these photoreceptors are structurally distinct from each other. In zebrafish, although quite different from rods and UV cones, RGB cones (red, green, and blue cones) are structurally similar and unite into mirror-symmetric pentamers (G-R-B-R-G) by adhesion. This structural commonality and unity suggest that a set of genes is commonly expressed only in RGB cones but not in other cells. Here, we report that the rainbow enhancers activate RGB cone-specific transcription of the ponli and crb2b genes. This study provides a starting point to study how RGB cone-specific transcription defines RGB cones' distinct functions for color vision." @default.
• W2588607672 created "2017-02-24" @default.
• W2588607672 creator A5024631831 @default.
• W2588607672 creator A5031366477 @default.
• W2588607672 creator A5043533542 @default.
• W2588607672 date "2017-02-13" @default.
• W2588607672 modified "2023-10-12" @default.
• W2588607672 title "<i>Rainbow</i>Enhancers Regulate Restrictive Transcription in Teleost Green, Red, and Blue Cones" @default.
• W2588607672 cites W1976117323 @default.
• W2588607672 cites W1982738614 @default.
• W2588607672 cites W1987510697 @default.
• W2588607672 cites W1987839415 @default.
• W2588607672 cites W1990419694 @default.
• W2588607672 cites W1993848738 @default.
• W2588607672 cites W1999967392 @default.
• W2588607672 cites W2000274486 @default.
• W2588607672 cites W2000643824 @default.
• W2588607672 cites W2011002931 @default.
• W2588607672 cites W2015689096 @default.
• W2588607672 cites W2018563312 @default.
• W2588607672 cites W2024622122 @default.
• W2588607672 cites W2037837211 @default.
• W2588607672 cites W2039007672 @default.
• W2588607672 cites W2044726214 @default.
• W2588607672 cites W2046681118 @default.
• W2588607672 cites W2047676549 @default.
• W2588607672 cites W2048501294 @default.
• W2588607672 cites W2054972298 @default.
• W2588607672 cites W2057692691 @default.
• W2588607672 cites W2061000133 @default.
• W2588607672 cites W2063658048 @default.
• W2588607672 cites W2066876408 @default.
• W2588607672 cites W2072414883 @default.
• W2588607672 cites W2074366705 @default.
• W2588607672 cites W2075386046 @default.
• W2588607672 cites W2079501676 @default.
• W2588607672 cites W2083073732 @default.
• W2588607672 cites W2094231737 @default.
• W2588607672 cites W2098188064 @default.
• W2588607672 cites W2100155631 @default.
• W2588607672 cites W2107277218 @default.
• W2588607672 cites W2111993777 @default.
• W2588607672 cites W2117526725 @default.
• W2588607672 cites W2128713736 @default.
• W2588607672 cites W2129656350 @default.
• W2588607672 cites W2129714574 @default.
• W2588607672 cites W2130796889 @default.
• W2588607672 cites W2131418016 @default.
• W2588607672 cites W2143931203 @default.
• W2588607672 cites W2148216753 @default.
• W2588607672 cites W2152611630 @default.
• W2588607672 cites W2154185079 @default.
• W2588607672 cites W2154401305 @default.
• W2588607672 cites W2161711244 @default.
• W2588607672 cites W2170466740 @default.
• W2588607672 cites W2192080449 @default.
• W2588607672 cites W4246645317 @default.
• W2588607672 doi "https://doi.org/10.1523/jneurosci.3421-16.2017" @default.
• W2588607672 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5354330" @default.
• W2588607672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28193687" @default.
• W2588607672 hasPublicationYear "2017" @default.
• W2588607672 type Work @default.
• W2588607672 sameAs 2588607672 @default.
• W2588607672 citedByCount "8" @default.
• W2588607672 countsByYear W25886076722018 @default.
• W2588607672 countsByYear W25886076722019 @default.
• W2588607672 countsByYear W25886076722020 @default.
• W2588607672 countsByYear W25886076722021 @default.
• W2588607672 countsByYear W25886076722023 @default.
• W2588607672 crossrefType "journal-article" @default.
• W2588607672 hasAuthorship W2588607672A5024631831 @default.
• W2588607672 hasAuthorship W2588607672A5031366477 @default.
• W2588607672 hasAuthorship W2588607672A5043533542 @default.
• W2588607672 hasBestOaLocation W25886076721 @default.
• W2588607672 hasConcept C104317684 @default.
• W2588607672 hasConcept C111936080 @default.
• W2588607672 hasConcept C138885662 @default.
• W2588607672 hasConcept C179926584 @default.
• W2588607672 hasConcept C202033177 @default.
• W2588607672 hasConcept C2776878037 @default.
• W2588607672 hasConcept C2780827179 @default.
• W2588607672 hasConcept C30028475 @default.
• W2588607672 hasConcept C41895202 @default.
• W2588607672 hasConcept C54355233 @default.
• W2588607672 hasConcept C59822182 @default.
• W2588607672 hasConcept C86339819 @default.
• W2588607672 hasConcept C86803240 @default.
• W2588607672 hasConcept C95444343 @default.
• W2588607672 hasConceptScore W2588607672C104317684 @default.
• W2588607672 hasConceptScore W2588607672C111936080 @default.
• W2588607672 hasConceptScore W2588607672C138885662 @default.
• W2588607672 hasConceptScore W2588607672C179926584 @default.
• W2588607672 hasConceptScore W2588607672C202033177 @default.
• W2588607672 hasConceptScore W2588607672C2776878037 @default.
• W2588607672 hasConceptScore W2588607672C2780827179 @default.
• W2588607672 hasConceptScore W2588607672C30028475 @default.
• W2588607672 hasConceptScore W2588607672C41895202 @default.
• W2588607672 hasConceptScore W2588607672C54355233 @default.

• next