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• W2588613504 endingPage "159" @default.
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• W2588613504 abstract "Direct oral anticoagulants (DOACs) are effective in preventing and treating venous thromboembolism, and preventing stroke in atrial fibrillation. Until recently, there has been no specific reversal agent for DOACs. Now, a specific antidote for the direct thrombin inhibitor, dabigatran has been approved for use, and antidotes for factor Xa inhibitors (rivaroxaban, apixaban and edoxaban) are being developed. We review the evidence for currently used and emerging reversal strategies, and discuss possible clinical implications, including increased prescription of DOACs, use of DOACs in clinical situations previously felt to pose too great a risk of bleeding, and use of reversal agents beyond currently approved indications." @default.
• W2588613504 created "2017-02-24" @default.
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• W2588613504 date "2017-03-01" @default.
• W2588613504 modified "2023-09-25" @default.
• W2588613504 title "Clinical implications of reversal agents for direct oral anticoagulants" @default.
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• W2588613504 doi "https://doi.org/10.2217/fca-2016-0070" @default.
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