FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588623168> ?p ?o ?g. }

• W2588623168 endingPage "1461" @default.
• W2588623168 startingPage "1454" @default.
• W2588623168 abstract "Androgenic compounds have been implicated in induction of endometrial atrophy yet the mechanisms of androgen effects on human endometrium have not been well studied. We hypothesized that androgens may promote their endometrial effects via modulation of progesterone receptor (PR) expression.Proliferative phase endometrial samples were collected at the time of hysterectomy. We evaluated the effect of the potent androgen 5α-dihydrotestosterone (DHT) on endometrial PR expression by treating human endometrial explants, endometrial stromal cells, and Ishikawa cells with DHT. Ishikawa cells were also treated with DHT ± the androgen receptor (AR) blocker flutamide. The PR-B, total PR messenger RNA (mRNA), and PR protein expression were assessed. Expression of cyclin D1 and D2 was checked as markers of cell proliferation.As expected, estradiol induced PR expression in isolated stromal cells, endometrial epithelial cells, and tissue explants. The DHT treatment also resulted in increased PR expression in endometrial explants and Ishikawa cells but not in stromal cells. Further, protein levels of both nuclear PR isoforms (PR-A and PR-B) were induced with the DHT treatment. Although flutamide treatment alone did not affect PR expression, flutamide diminished androgen-induced upregulation of PR in both endometrial explants and Ishikawa cells. Although estradiol induced both cyclin D1 and cyclin D2 mRNA, DHT did not induce these markers of cell proliferation.Androgens may mediate endometrial effects through upregulation of PR gene and protein expression. Endometrial PR upregulation by androgens is mediated, at least in part, through AR." @default.
• W2588623168 created "2017-02-24" @default.
• W2588623168 creator A5001115115 @default.
• W2588623168 creator A5010802182 @default.
• W2588623168 creator A5027825594 @default.
• W2588623168 creator A5042078280 @default.
• W2588623168 creator A5066225680 @default.
• W2588623168 creator A5088036401 @default.
• W2588623168 date "2017-10-01" @default.
• W2588623168 modified "2023-09-24" @default.
• W2588623168 title "Androgens Upregulate Endometrial Epithelial Progesterone Receptor Expression: Potential Implications for Endometriosis" @default.
• W2588623168 cites W112482003 @default.
• W2588623168 cites W1482448052 @default.
• W2588623168 cites W1484666375 @default.
• W2588623168 cites W1523117771 @default.
• W2588623168 cites W185805025 @default.
• W2588623168 cites W1963499242 @default.
• W2588623168 cites W1965397941 @default.
• W2588623168 cites W1981817227 @default.
• W2588623168 cites W1996446365 @default.
• W2588623168 cites W1998040747 @default.
• W2588623168 cites W2009231867 @default.
• W2588623168 cites W2015065898 @default.
• W2588623168 cites W2017208105 @default.
• W2588623168 cites W2019792229 @default.
• W2588623168 cites W2020179235 @default.
• W2588623168 cites W2023298070 @default.
• W2588623168 cites W2023781708 @default.
• W2588623168 cites W2029948820 @default.
• W2588623168 cites W2030686715 @default.
• W2588623168 cites W2038052756 @default.
• W2588623168 cites W2044094125 @default.
• W2588623168 cites W2052591056 @default.
• W2588623168 cites W2054148469 @default.
• W2588623168 cites W2060294108 @default.
• W2588623168 cites W2108405868 @default.
• W2588623168 cites W2112309922 @default.
• W2588623168 cites W2145057288 @default.
• W2588623168 cites W2148368274 @default.
• W2588623168 cites W2159587878 @default.
• W2588623168 cites W2159777458 @default.
• W2588623168 cites W2398981566 @default.
• W2588623168 cites W2402480798 @default.
• W2588623168 cites W2407664671 @default.
• W2588623168 cites W2428876759 @default.
• W2588623168 cites W4248793083 @default.
• W2588623168 cites W84683815 @default.
• W2588623168 doi "https://doi.org/10.1177/1933719117691145" @default.
• W2588623168 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6344819" @default.
• W2588623168 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28891417" @default.
• W2588623168 hasPublicationYear "2017" @default.
• W2588623168 type Work @default.
• W2588623168 sameAs 2588623168 @default.
• W2588623168 citedByCount "17" @default.
• W2588623168 countsByYear W25886231682018 @default.
• W2588623168 countsByYear W25886231682019 @default.
• W2588623168 countsByYear W25886231682020 @default.
• W2588623168 countsByYear W25886231682021 @default.
• W2588623168 countsByYear W25886231682022 @default.
• W2588623168 countsByYear W25886231682023 @default.
• W2588623168 crossrefType "journal-article" @default.
• W2588623168 hasAuthorship W2588623168A5001115115 @default.
• W2588623168 hasAuthorship W2588623168A5010802182 @default.
• W2588623168 hasAuthorship W2588623168A5027825594 @default.
• W2588623168 hasAuthorship W2588623168A5042078280 @default.
• W2588623168 hasAuthorship W2588623168A5066225680 @default.
• W2588623168 hasAuthorship W2588623168A5088036401 @default.
• W2588623168 hasBestOaLocation W25886231682 @default.
• W2588623168 hasConcept C104317684 @default.
• W2588623168 hasConcept C121608353 @default.
• W2588623168 hasConcept C126322002 @default.
• W2588623168 hasConcept C127561419 @default.
• W2588623168 hasConcept C134018914 @default.
• W2588623168 hasConcept C16930146 @default.
• W2588623168 hasConcept C185592680 @default.
• W2588623168 hasConcept C199835354 @default.
• W2588623168 hasConcept C2777911890 @default.
• W2588623168 hasConcept C2778313021 @default.
• W2588623168 hasConcept C2779742232 @default.
• W2588623168 hasConcept C2779881493 @default.
• W2588623168 hasConcept C2780192828 @default.
• W2588623168 hasConcept C29537977 @default.
• W2588623168 hasConcept C530470458 @default.
• W2588623168 hasConcept C55493867 @default.
• W2588623168 hasConcept C61367390 @default.
• W2588623168 hasConcept C71315377 @default.
• W2588623168 hasConcept C71924100 @default.
• W2588623168 hasConcept C84606932 @default.
• W2588623168 hasConcept C86803240 @default.
• W2588623168 hasConcept C98717036 @default.
• W2588623168 hasConceptScore W2588623168C104317684 @default.
• W2588623168 hasConceptScore W2588623168C121608353 @default.
• W2588623168 hasConceptScore W2588623168C126322002 @default.
• W2588623168 hasConceptScore W2588623168C127561419 @default.
• W2588623168 hasConceptScore W2588623168C134018914 @default.
• W2588623168 hasConceptScore W2588623168C16930146 @default.
• W2588623168 hasConceptScore W2588623168C185592680 @default.
• W2588623168 hasConceptScore W2588623168C199835354 @default.

• next