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- W2588647584 abstract "Thermal injury in iats leads to an impairment of polymorphonuclear leu- kocyte (PMN) functions, pa-ticularly oxidative metabolism and phosphoinositide turnover. As prostaglandin E2, which has immunosuppressive properties, is released in high levels after bum trauma, we investigated the in vitro and in vivo effects of a nonstemidal antiinflammatory drag, niflumic acid, on oxidative and phosphoinositide metabolism in PMNs from healthy and burned rats. Given the role of fluoride ions on PMN, the influence of nif umic acid was compared with that of sodium fluoride (NaF) at equivalent doses of )7-. In vitro, niflumic acid and sodium fluoride had no effect on oxidative metabolisra in stimulated by formyl methionyl-leucyl-phenylala- nine (FMLP) or opsonized zymosan (OZ) or nonstimulated PMNs from healthy and burned rats. Niflumic acid sli?~htly increased the production of inositol phosphate by nonstimulated PMNs from healthy and burned rats. Niflumic acid and NaF partly restored the stimulating effect of FMLP on inositol phosphate production by PMNs from burned rats. In vivo treatment with niflumic acid and NaF increased the oxidative metabolism of PMNs from burned rats but not healthy rats. Niflumic acid, more than NaF, restored the activity of both stimulants on phosphoinositide metabolism in PMNs from burned rats. In conclusion, at non-antiinflammatory doses, while inhib- iting cyclooxygenase activity, niflumic acid exerts a complex effect on the burn~ induced depression of PMN functions. The fluoride anion induces similar but gen- erally weaker effects and see-as to be involved in the restoring effects of niflumic acid on PMN functions in bu~nned rats." @default.
- W2588647584 created "2017-02-24" @default.
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- W2588647584 date "1992-01-01" @default.
- W2588647584 modified "2023-09-23" @default.
- W2588647584 title "EFFECTS OF NIFLUMIC ACID ON POLYPHOSPH(3INOS ITIDE AND OXIDATIVE METABOLISM IN POLYMORPHONUCLEA R LEUKOCYTES FROM HEALTHY AND THERMALLY INJURED RATS M. TISSOT, ~ M. RO ~H-ARVEILLER, J. FONTAGNE, 2 and J. P. GIROUD I" @default.
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