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• W2588692589 abstract "(Cancer Cell 24, 213–228; August 12, 2013) Following the publication of this paper, the authors noticed that Figures S2A–S2D in the online Supplemental Information document were inadvertently replaced by Figure S1 and contained a few typographical errors. The online Supplemental Information has now been replaced with a corrected document. Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of CancerPatra et al.Cancer CellAugust 1, 2013In BriefAccelerated glucose metabolism is a common feature of cancer cells. Hexokinases catalyze the first committed step of glucose metabolism. Hexokinase 2 (HK2) is expressed at high level in cancer cells, but only in a limited number of normal adult tissues. Using Hk2 conditional knockout mice, we showed that HK2 is required for tumor initiation and maintenance in mouse models of KRas-driven lung cancer, and ErbB2-driven breast cancer, despite continued HK1 expression. Similarly, HK2 ablation inhibits the neoplastic phenotype of human lung and breast cancer cells in vitro and in vivo. Full-Text PDF Open Archive" @default.
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• W2588692589 date "2013-09-01" @default.
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• W2588692589 title "Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer" @default.
• W2588692589 doi "https://doi.org/10.1016/j.ccr.2013.08.029" @default.
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