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- W2588743016 abstract "Methods. Patients with an office systolic blood pressure (BP)>140 mmHg or diastolic BP >90 mmHg, despite treatment with atleast 3 antihypertensive drugs including a diuretic, wererandomly assigned to receive spironolactone or a placebo for 8weeks in a double-blind, placebo-controlled, multicentre trial(ASPIRANT). Background. There are currently limited data onwhether the effect of spironolactone in patients with resistantarterial hypertension depends on age and sex. Results. Analyseswere done on 55 patients treated with spironolactone and 56patients treated with placebo. Significant reductions of officesystolic BP (-8.9 +/- 6.7 mmHg, P=0.012), 24-h ABPM systolic BP(-7.9 +/- 7.2 mmHg, P=0.032) and ABPM day-time systolic BP(-7.5 +/- 7.1 mmHg) after 8 weeks of spironolactone treatment,compared to placebo, were only observed in patients with amedian age 62 years, and is effective to a similar extent inmen and women." @default.
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- W2588743016 date "2014-01-01" @default.
- W2588743016 modified "2023-10-18" @default.
- W2588743016 title "Effect of spironolactone in patients with resistant arterialhypertension in relation to age and sex: Insights from theaspirant trial" @default.
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