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- W2588755013 abstract "Lung cancer is the leading cause of cancer deaths worldwide, with the majority of mortality resulting from metastatic spread. However, the molecular mechanism by which cancer cells acquire the ability to disseminate from primary tumors, seed distant organs, and grow into tissue-destructive metastases remains incompletely understood. We combined tumor barcoding in a mouse model of human lung adenocarcinoma with unbiased genomic approaches to identify a transcriptional program that confers metastatic ability and predicts patient survival. Small-scale in vivo screening identified several genes, including Cd109, that encode novel pro-metastatic factors. We uncovered signaling mediated by Janus kinases (Jaks) and the transcription factor Stat3 as a critical, pharmacologically targetable effector of CD109-driven lung cancer metastasis. In summary, by coupling the systematic genomic analysis of purified cancer cells in distinct malignant states from mouse models with extensive human validation, we uncovered several key regulators of metastatic ability, including an actionable pro-metastatic CD109-Jak-Stat3 axis." @default.
- W2588755013 created "2017-02-24" @default.
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- W2588755013 date "2017-02-13" @default.
- W2588755013 modified "2023-10-18" @default.
- W2588755013 title "Molecular definition of a metastatic lung cancer state reveals a targetable CD109–Janus kinase–Stat axis" @default.
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- W2588755013 cites W1553224996 @default.
- W2588755013 cites W1949238489 @default.
- W2588755013 cites W1964636114 @default.
- W2588755013 cites W1968342623 @default.
- W2588755013 cites W1971886895 @default.
- W2588755013 cites W1978286483 @default.
- W2588755013 cites W1979335806 @default.
- W2588755013 cites W1979562553 @default.
- W2588755013 cites W1981799488 @default.
- W2588755013 cites W1984237039 @default.
- W2588755013 cites W1993023683 @default.
- W2588755013 cites W1994772304 @default.
- W2588755013 cites W2001962665 @default.
- W2588755013 cites W2002782759 @default.
- W2588755013 cites W2007179675 @default.
- W2588755013 cites W2011085368 @default.
- W2588755013 cites W2012573463 @default.
- W2588755013 cites W2016293785 @default.
- W2588755013 cites W2018336040 @default.
- W2588755013 cites W2019011312 @default.
- W2588755013 cites W2027146979 @default.
- W2588755013 cites W2031211461 @default.
- W2588755013 cites W2032019019 @default.
- W2588755013 cites W2032674547 @default.
- W2588755013 cites W2033412499 @default.
- W2588755013 cites W2035134361 @default.
- W2588755013 cites W2036008499 @default.
- W2588755013 cites W2036858259 @default.
- W2588755013 cites W2037298700 @default.
- W2588755013 cites W2045949302 @default.
- W2588755013 cites W2050389860 @default.
- W2588755013 cites W2057151160 @default.
- W2588755013 cites W2065128082 @default.
- W2588755013 cites W2066968675 @default.
- W2588755013 cites W2072349948 @default.
- W2588755013 cites W2074356752 @default.
- W2588755013 cites W2079645940 @default.
- W2588755013 cites W2081098333 @default.
- W2588755013 cites W2089370460 @default.
- W2588755013 cites W2091596054 @default.
- W2588755013 cites W2100305481 @default.
- W2588755013 cites W2103441770 @default.
- W2588755013 cites W2104224322 @default.
- W2588755013 cites W2107282910 @default.
- W2588755013 cites W2108234281 @default.
- W2588755013 cites W2114843025 @default.
- W2588755013 cites W2117419186 @default.
- W2588755013 cites W2119180969 @default.
- W2588755013 cites W2122758063 @default.
- W2588755013 cites W2124163621 @default.
- W2588755013 cites W2126087693 @default.
- W2588755013 cites W2126496132 @default.
- W2588755013 cites W2130410032 @default.
- W2588755013 cites W2131876608 @default.
- W2588755013 cites W2132165198 @default.
- W2588755013 cites W2137499573 @default.
- W2588755013 cites W2143616664 @default.
- W2588755013 cites W2146040216 @default.
- W2588755013 cites W2149468135 @default.
- W2588755013 cites W2154283358 @default.
- W2588755013 cites W2163798887 @default.
- W2588755013 cites W2171972690 @default.
- W2588755013 cites W2180481128 @default.
- W2588755013 cites W2235523093 @default.
- W2588755013 cites W2266814182 @default.
- W2588755013 cites W2280923709 @default.
- W2588755013 cites W2320138981 @default.
- W2588755013 cites W2340408307 @default.
- W2588755013 cites W2461903592 @default.
- W2588755013 cites W3099478002 @default.
- W2588755013 cites W4211214747 @default.
- W2588755013 cites W4243190969 @default.
- W2588755013 doi "https://doi.org/10.1038/nm.4285" @default.
- W2588755013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6453542" @default.