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- W2588760908 abstract "Learning genes in mature neurons are uniquely suited to respond rapidly to specific environmental stimuli. Expression of individual learning genes, therefore, requires regulatory mechanisms that have the flexibility to respond with transcriptional activation or repression to select appropriate physiological and behavioral responses. Among the mechanisms that equip genes to respond adaptively are bivalent domains. These are specific histone modifications localized to gene promoters that are characteristic of both gene activation and repression, and have been studied primarily for developmental genes in embryonic stem cells. In this review, studies of the epigenetic regulation of learning genes in neurons, particularly the brain-derived neurotrophic factor gene (BDNF), by methylation/demethylation and chromatin modifications in the context of learning and memory will be highlighted. Because of the unique function of learning genes in the mature brain, it is proposed that bivalent domains are a characteristic feature of the chromatin landscape surrounding their promoters. This allows them to be “poised” for rapid response to activate or repress gene expression depending on environmental stimuli." @default.
- W2588760908 created "2017-02-24" @default.
- W2588760908 creator A5063364058 @default.
- W2588760908 date "2017-02-11" @default.
- W2588760908 modified "2023-09-27" @default.
- W2588760908 title "Primetime for Learning Genes" @default.
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- W2588760908 doi "https://doi.org/10.3390/genes8020069" @default.
- W2588760908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5333058" @default.
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