FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588793313> ?p ?o ?g. }

• W2588793313 abstract "Abstract Band 3 was initially described as the first member of the anion exchanger family (AE1). It is an integral membrane protein, initially characterized in erythrocytes. The AE family is encoded by four genes, AE1, AE2, AE3 and AE4. Three AE1 isoforms have been described up to now: erythroid (eAE1), kidney (kAE1), and cardiac (cAE1). Increased expression and activity of AE1 and AE3, as well as of the Na+/H+ exchanger have been demonstrated in hypertrophic myocardium of rats. A physical association of band 3 with cardiac actin has been previously described by our group, using yeast two hybrid screening. It has also been suggested that this binding occurs in the intercalated disc, a site of cell-cell contact and attachment of the sarcomere to the plasma membrane. In the present study, immunolocalization analysis by confocal laser scanning microscopy was used to investigate the band 3 re-organization in neonatal cardiomyocytes (Wistar rats 1 to 2-day-old) submitted to different stimuli, such as pH changing or mechanical stretch (a model leading to cardiac hypertrophy). In the untreated cells, band 3 was dispersedly distributed in the cytoplasm, preferentially in the perinuclear region. On the other hand, when these cells were submitted to cyclic stretch (2 hours), band 3 appears between actin filaments, in the sarcomeric units. Similar distribution was showed in cardiac cells submitted to alkali loading (pH 8.9 for 2 hours). However, in experiments where the culture medium was pH 6.8, band 3 was dispersed in the cytoplasm, but was not concentrated in the perinuclear region. Intracellular pH (pHi) is a major regulator of diverse cellular processes including metabolic pathways, Ca2+ homeostasis, cell contractility, cell excitability and cell death; a rise in pHi activates Cl−/HCO3− exchanger. On the other hand, the mechanical stretch stimulates a rapid secretion of Angiotensin II, rise of pHi and activation of intracellular signaling molecules such as protein kinase C and tyrosine kinases. These processes induce cell proliferation, cardiac hypertrophy and reorganization of actin cytoskeleton. The demonstration of reorganization of band 3 and its localization in the sarcomeric units after these stimuli suggest that band 3 is involved in the cardiac hypertrophy physiopathology. Band 3 could function as an anchorage for the contractile apparatus, as well as in the transport of anions in the myocardium, which are well described processes in normal erythrocytes." @default.
• W2588793313 created "2017-02-24" @default.
• W2588793313 creator A5039343557 @default.
• W2588793313 creator A5052529953 @default.
• W2588793313 creator A5058183730 @default.
• W2588793313 creator A5061310394 @default.
• W2588793313 creator A5067713063 @default.
• W2588793313 creator A5071618928 @default.
• W2588793313 creator A5085890026 @default.
• W2588793313 date "2006-11-16" @default.
• W2588793313 modified "2023-10-01" @default.
• W2588793313 title "Re-Organization of Cardiac Band 3 (cAE1) in Neonatal Cardiomyocytes Submitted to Alkali Loading." @default.
• W2588793313 doi "https://doi.org/10.1182/blood.v108.11.3744.3744" @default.
• W2588793313 hasPublicationYear "2006" @default.
• W2588793313 type Work @default.
• W2588793313 sameAs 2588793313 @default.
• W2588793313 citedByCount "0" @default.
• W2588793313 crossrefType "journal-article" @default.
• W2588793313 hasAuthorship W2588793313A5039343557 @default.
• W2588793313 hasAuthorship W2588793313A5052529953 @default.
• W2588793313 hasAuthorship W2588793313A5058183730 @default.
• W2588793313 hasAuthorship W2588793313A5061310394 @default.
• W2588793313 hasAuthorship W2588793313A5067713063 @default.
• W2588793313 hasAuthorship W2588793313A5071618928 @default.
• W2588793313 hasAuthorship W2588793313A5085890026 @default.
• W2588793313 hasConcept C104317684 @default.
• W2588793313 hasConcept C12554922 @default.
• W2588793313 hasConcept C125705527 @default.
• W2588793313 hasConcept C144647389 @default.
• W2588793313 hasConcept C153911025 @default.
• W2588793313 hasConcept C158157758 @default.
• W2588793313 hasConcept C185592680 @default.
• W2588793313 hasConcept C190062978 @default.
• W2588793313 hasConcept C207200792 @default.
• W2588793313 hasConcept C2776589458 @default.
• W2588793313 hasConcept C41625074 @default.
• W2588793313 hasConcept C53345823 @default.
• W2588793313 hasConcept C55493867 @default.
• W2588793313 hasConcept C68731436 @default.
• W2588793313 hasConcept C79879829 @default.
• W2588793313 hasConcept C86803240 @default.
• W2588793313 hasConcept C95444343 @default.
• W2588793313 hasConceptScore W2588793313C104317684 @default.
• W2588793313 hasConceptScore W2588793313C12554922 @default.
• W2588793313 hasConceptScore W2588793313C125705527 @default.
• W2588793313 hasConceptScore W2588793313C144647389 @default.
• W2588793313 hasConceptScore W2588793313C153911025 @default.
• W2588793313 hasConceptScore W2588793313C158157758 @default.
• W2588793313 hasConceptScore W2588793313C185592680 @default.
• W2588793313 hasConceptScore W2588793313C190062978 @default.
• W2588793313 hasConceptScore W2588793313C207200792 @default.
• W2588793313 hasConceptScore W2588793313C2776589458 @default.
• W2588793313 hasConceptScore W2588793313C41625074 @default.
• W2588793313 hasConceptScore W2588793313C53345823 @default.
• W2588793313 hasConceptScore W2588793313C55493867 @default.
• W2588793313 hasConceptScore W2588793313C68731436 @default.
• W2588793313 hasConceptScore W2588793313C79879829 @default.
• W2588793313 hasConceptScore W2588793313C86803240 @default.
• W2588793313 hasConceptScore W2588793313C95444343 @default.
• W2588793313 hasLocation W25887933131 @default.
• W2588793313 hasOpenAccess W2588793313 @default.
• W2588793313 hasPrimaryLocation W25887933131 @default.
• W2588793313 hasRelatedWork W1515638484 @default.
• W2588793313 hasRelatedWork W1586288730 @default.
• W2588793313 hasRelatedWork W195847259 @default.
• W2588793313 hasRelatedWork W1977978400 @default.
• W2588793313 hasRelatedWork W2067076691 @default.
• W2588793313 hasRelatedWork W2074772642 @default.
• W2588793313 hasRelatedWork W2085868893 @default.
• W2588793313 hasRelatedWork W2116752236 @default.
• W2588793313 hasRelatedWork W2116909714 @default.
• W2588793313 hasRelatedWork W2588793313 @default.
• W2588793313 isParatext "false" @default.
• W2588793313 isRetracted "false" @default.
• W2588793313 magId "2588793313" @default.
• W2588793313 workType "article" @default.