FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588798947> ?p ?o ?g. }

• W2588798947 endingPage "400" @default.
• W2588798947 startingPage "390" @default.
• W2588798947 abstract "Evaluation of the effects of linuron and S-metolachlor on apical, biochemical and transcriptional endpoints in zebrafish (Danio rerio) early life stages was the main purpose of this work. Embryos were exposed for 96h to a range of concentrations of each herbicide to determine lethal and sub-lethal effects on apical (e.g. malformations, hatching) and biochemical parameters (cholinesterase, ChE; catalase, CAT; glutathione S-transferase, GST; lipid peroxidation, LPO and lactate dehydrogenase, LDH). To evaluate endocrine disruption effects, embryos were exposed during 96h to 0.88mg/L linuron and 9.66mg/L S-metolachlor, isolated or in binary mixture. Expression of a suite of genes involved in HPT, HPG and HPA-axis was then assessed. Highest concentration of linuron (5.0mg/L) decreased hatching rate to 5% and 70.0mg/L S-metolachlor completely inhibited hatching, about 100%. Both herbicides impaired development by inducing several malformations (100% in 5.0mg/L linuron and 70.0mg/L S-metolachlor). Linuron only affected GST and CAT at concentrations of 0.25 and 0.0025mg/L, respectively. S-metolachlor induced GST (to 256%), inhibited ChE (to 61%) and LDH (to 60%) and reduced LPO levels (to 63%). Linuron isolated treatment seems to have an estrogenic mode of action due to the observed induction of vtg1. Exposure to S-metolachlor seems to interfere with steroidogenesis and with HPT and HPA-axis, since it has inhibited cyp19a2, TSHβ and CRH gene expression. In addition to vtg1 induction and CRH inhibition, herbicide combination also induced sox9b that has a role in regulation of sexual development in zebrafish. This study pointed out adverse effects of linuron and S-metolachlor, namely impairment of neurotransmission and energy production, induction of steroidogenesis, and interference with HPT and HPA-axis. These results contributed to elucidate modes of action of linuron and S-metolachlor in zebrafish embryo model. Furthermore, gene expression patterns obtained are indicative of endocrine disruption action of these herbicides." @default.
• W2588798947 created "2017-02-24" @default.
• W2588798947 creator A5008176015 @default.
• W2588798947 creator A5010933817 @default.
• W2588798947 creator A5024820056 @default.
• W2588798947 creator A5067511868 @default.
• W2588798947 creator A5068920816 @default.
• W2588798947 date "2017-05-01" @default.
• W2588798947 modified "2023-10-16" @default.
• W2588798947 title "Endocrine and physiological effects of linuron and S-metolachlor in zebrafish developing embryos" @default.
• W2588798947 cites W1162386983 @default.
• W2588798947 cites W1536923222 @default.
• W2588798947 cites W1708459719 @default.
• W2588798947 cites W1819170026 @default.
• W2588798947 cites W1883557756 @default.
• W2588798947 cites W1966568699 @default.
• W2588798947 cites W1968619649 @default.
• W2588798947 cites W1970321386 @default.
• W2588798947 cites W1971048984 @default.
• W2588798947 cites W197228448 @default.
• W2588798947 cites W1972586432 @default.
• W2588798947 cites W1973830738 @default.
• W2588798947 cites W1978806457 @default.
• W2588798947 cites W1981658622 @default.
• W2588798947 cites W1981880556 @default.
• W2588798947 cites W1982440565 @default.
• W2588798947 cites W1983310681 @default.
• W2588798947 cites W1983689215 @default.
• W2588798947 cites W1985956131 @default.
• W2588798947 cites W1990100049 @default.
• W2588798947 cites W1991225204 @default.
• W2588798947 cites W1992803954 @default.
• W2588798947 cites W1993989119 @default.
• W2588798947 cites W2006464840 @default.
• W2588798947 cites W2010090482 @default.
• W2588798947 cites W2010175494 @default.
• W2588798947 cites W2011681469 @default.
• W2588798947 cites W2012278340 @default.
• W2588798947 cites W2012910224 @default.
• W2588798947 cites W2016180266 @default.
• W2588798947 cites W2017358077 @default.
• W2588798947 cites W2021592625 @default.
• W2588798947 cites W2026486343 @default.
• W2588798947 cites W2030382945 @default.
• W2588798947 cites W2031493473 @default.
• W2588798947 cites W2032978676 @default.
• W2588798947 cites W2036138233 @default.
• W2588798947 cites W2039252349 @default.
• W2588798947 cites W2042809933 @default.
• W2588798947 cites W2048857248 @default.
• W2588798947 cites W2049897699 @default.
• W2588798947 cites W2053893947 @default.
• W2588798947 cites W2056663411 @default.
• W2588798947 cites W2058333746 @default.
• W2588798947 cites W2062115282 @default.
• W2588798947 cites W2064503586 @default.
• W2588798947 cites W2070800302 @default.
• W2588798947 cites W2074505831 @default.
• W2588798947 cites W2074728452 @default.
• W2588798947 cites W2076690025 @default.
• W2588798947 cites W2083489455 @default.
• W2588798947 cites W2085498925 @default.
• W2588798947 cites W2086002759 @default.
• W2588798947 cites W2086111284 @default.
• W2588798947 cites W2086573507 @default.
• W2588798947 cites W2089342011 @default.
• W2588798947 cites W2091538781 @default.
• W2588798947 cites W2093851297 @default.
• W2588798947 cites W2095077803 @default.
• W2588798947 cites W2097600921 @default.
• W2588798947 cites W2099249565 @default.
• W2588798947 cites W2105976044 @default.
• W2588798947 cites W2112213136 @default.
• W2588798947 cites W2117794875 @default.
• W2588798947 cites W2125349610 @default.
• W2588798947 cites W2125541269 @default.
• W2588798947 cites W2129222401 @default.
• W2588798947 cites W2132836262 @default.
• W2588798947 cites W2137340670 @default.
• W2588798947 cites W2139826516 @default.
• W2588798947 cites W2145526497 @default.
• W2588798947 cites W2149623765 @default.
• W2588798947 cites W2158406641 @default.
• W2588798947 cites W2159866427 @default.
• W2588798947 cites W2162581076 @default.
• W2588798947 cites W2172672766 @default.
• W2588798947 cites W2235301672 @default.
• W2588798947 cites W4248112001 @default.
• W2588798947 cites W4293247451 @default.
• W2588798947 doi "https://doi.org/10.1016/j.scitotenv.2016.11.153" @default.
• W2588798947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28209406" @default.
• W2588798947 hasPublicationYear "2017" @default.
• W2588798947 type Work @default.
• W2588798947 sameAs 2588798947 @default.
• W2588798947 citedByCount "54" @default.
• W2588798947 countsByYear W25887989472017 @default.
• W2588798947 countsByYear W25887989472018 @default.
• W2588798947 countsByYear W25887989472019 @default.

• next