FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588826493> ?p ?o ?g. }

• W2588826493 endingPage "852" @default.
• W2588826493 startingPage "846" @default.
• W2588826493 abstract "Most solid cancers spread to new sites via the lymphatics before hematogenous dissemination. However, only a small fraction of an intravenously administered anti‐cancer drug enters the lymphatic system to reach metastatic lymph nodes ( LN ). Here, we show that the enhanced permeability and retention ( EPR ) effect is not induced during the early stages of LN metastasis. Luciferase‐expressing tumor cells were injected into the subiliac LN of the MXH 10/Mo‐ lpr / lpr mouse to induce metastasis to the proper axillary LN ( PALN ). In vivo biofluorescence imaging was used to confirm metastasis induction and to quantify the EPR effect, measured as PALN accumulation of intravenously injected indocyanine green ( ICG ) liposomes. PALN blood vessel volume changes were measured by contrast‐enhanced high‐frequency ultrasound imaging. The volume and density of blood vessels in the PALN increased until day 29 after inoculation, whereas the LN volume remained constant. ICG retention was first detected on day 29 post‐inoculation. While CD 31‐positive cells increased up to day 29 post‐inoculation, α‐smooth muscle actin‐positive cells were detected on day 29 post‐inoculation for the first time. These results suggest that the EPR effect was not induced in the early stages of LN metastasis; therefore, systemic chemotherapy would likely not be beneficial during the early stages of LN metastasis. The development of an alternative drug delivery system, independent of the EPR effect, is required for the treatment of LN metastasis." @default.
• W2588826493 created "2017-02-24" @default.
• W2588826493 creator A5009963480 @default.
• W2588826493 creator A5013795138 @default.
• W2588826493 creator A5035552843 @default.
• W2588826493 creator A5056831192 @default.
• W2588826493 creator A5066708522 @default.
• W2588826493 creator A5076602457 @default.
• W2588826493 creator A5077958789 @default.
• W2588826493 date "2017-05-01" @default.
• W2588826493 modified "2023-10-16" @default.
• W2588826493 title "Evaluation of the enhanced permeability and retention effect in the early stages of lymph node metastasis" @default.
• W2588826493 cites W1974443063 @default.
• W2588826493 cites W1975088956 @default.
• W2588826493 cites W2001692133 @default.
• W2588826493 cites W2006393464 @default.
• W2588826493 cites W2013687680 @default.
• W2588826493 cites W2029891359 @default.
• W2588826493 cites W2039668426 @default.
• W2588826493 cites W2046635748 @default.
• W2588826493 cites W2049481178 @default.
• W2588826493 cites W2064253548 @default.
• W2588826493 cites W2085850479 @default.
• W2588826493 cites W2154964159 @default.
• W2588826493 cites W2198386817 @default.
• W2588826493 cites W2201914086 @default.
• W2588826493 cites W2229982732 @default.
• W2588826493 cites W2316408327 @default.
• W2588826493 cites W2516627384 @default.
• W2588826493 cites W4229615284 @default.
• W2588826493 doi "https://doi.org/10.1111/cas.13206" @default.
• W2588826493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5448659" @default.
• W2588826493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28211204" @default.
• W2588826493 hasPublicationYear "2017" @default.
• W2588826493 type Work @default.
• W2588826493 sameAs 2588826493 @default.
• W2588826493 citedByCount "46" @default.
• W2588826493 countsByYear W25888264932017 @default.
• W2588826493 countsByYear W25888264932018 @default.
• W2588826493 countsByYear W25888264932019 @default.
• W2588826493 countsByYear W25888264932020 @default.
• W2588826493 countsByYear W25888264932021 @default.
• W2588826493 countsByYear W25888264932022 @default.
• W2588826493 countsByYear W25888264932023 @default.
• W2588826493 crossrefType "journal-article" @default.
• W2588826493 hasAuthorship W2588826493A5009963480 @default.
• W2588826493 hasAuthorship W2588826493A5013795138 @default.
• W2588826493 hasAuthorship W2588826493A5035552843 @default.
• W2588826493 hasAuthorship W2588826493A5056831192 @default.
• W2588826493 hasAuthorship W2588826493A5066708522 @default.
• W2588826493 hasAuthorship W2588826493A5076602457 @default.
• W2588826493 hasAuthorship W2588826493A5077958789 @default.
• W2588826493 hasBestOaLocation W25888264931 @default.
• W2588826493 hasConcept C113045295 @default.
• W2588826493 hasConcept C120882062 @default.
• W2588826493 hasConcept C121608353 @default.
• W2588826493 hasConcept C126322002 @default.
• W2588826493 hasConcept C142724271 @default.
• W2588826493 hasConcept C150903083 @default.
• W2588826493 hasConcept C181152851 @default.
• W2588826493 hasConcept C185592680 @default.
• W2588826493 hasConcept C207001950 @default.
• W2588826493 hasConcept C2776694085 @default.
• W2588826493 hasConcept C2777649898 @default.
• W2588826493 hasConcept C2779013556 @default.
• W2588826493 hasConcept C2779720271 @default.
• W2588826493 hasConcept C2780849966 @default.
• W2588826493 hasConcept C2781065829 @default.
• W2588826493 hasConcept C2989005 @default.
• W2588826493 hasConcept C41625074 @default.
• W2588826493 hasConcept C502942594 @default.
• W2588826493 hasConcept C55493867 @default.
• W2588826493 hasConcept C71924100 @default.
• W2588826493 hasConcept C86803240 @default.
• W2588826493 hasConceptScore W2588826493C113045295 @default.
• W2588826493 hasConceptScore W2588826493C120882062 @default.
• W2588826493 hasConceptScore W2588826493C121608353 @default.
• W2588826493 hasConceptScore W2588826493C126322002 @default.
• W2588826493 hasConceptScore W2588826493C142724271 @default.
• W2588826493 hasConceptScore W2588826493C150903083 @default.
• W2588826493 hasConceptScore W2588826493C181152851 @default.
• W2588826493 hasConceptScore W2588826493C185592680 @default.
• W2588826493 hasConceptScore W2588826493C207001950 @default.
• W2588826493 hasConceptScore W2588826493C2776694085 @default.
• W2588826493 hasConceptScore W2588826493C2777649898 @default.
• W2588826493 hasConceptScore W2588826493C2779013556 @default.
• W2588826493 hasConceptScore W2588826493C2779720271 @default.
• W2588826493 hasConceptScore W2588826493C2780849966 @default.
• W2588826493 hasConceptScore W2588826493C2781065829 @default.
• W2588826493 hasConceptScore W2588826493C2989005 @default.
• W2588826493 hasConceptScore W2588826493C41625074 @default.
• W2588826493 hasConceptScore W2588826493C502942594 @default.
• W2588826493 hasConceptScore W2588826493C55493867 @default.
• W2588826493 hasConceptScore W2588826493C71924100 @default.
• W2588826493 hasConceptScore W2588826493C86803240 @default.
• W2588826493 hasFunder F4320334764 @default.
• W2588826493 hasIssue "5" @default.
• W2588826493 hasLocation W25888264931 @default.

• next