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• W2588827064 endingPage "2024" @default.
• W2588827064 startingPage "2014" @default.
• W2588827064 abstract "Electrical stimulation of neuronal tissue is a promising strategy to treat a variety of neurological disorders. The mechanism of neuronal activation by external electrical stimulation is governed by voltage-gated ion channels. This stimulus, typically brief in nature, leads to membrane potential depolarization, which increases ion flow across the membrane by increasing the open probability of these voltage-gated channels. In spiking neurons, it is activation of voltage-gated sodium channels (Na V channels) that leads to action potential generation. However, several other types of voltage-gated channels are expressed that also respond to electrical stimulation. In this study, we examine the response of voltage-gated potassium channels (K V channels) to brief electrical stimulation by whole cell patch-clamp electrophysiology and computational modeling. We show that nonspiking amacrine neurons of the retina exhibit a large variety of responses to stimulation, driven by different K V -channel subtypes. Computational modeling reveals substantial differences in the response of specific K V -channel subtypes that is dependent on channel kinetics. This suggests that the expression levels of different K V -channel subtypes in retinal neurons are a crucial predictor of the response that can be obtained. These data expand our knowledge of the mechanisms of neuronal activation and suggest that K V -channel expression is an important determinant of the sensitivity of neurons to electrical stimulation. NEW & NOTEWORTHY This paper describes the response of various voltage-gated potassium channels (K V channels) to brief electrical stimulation, such as is applied during prosthetic electrical stimulation. We show that the pattern of response greatly varies between K V channel subtypes depending on activation and inactivation kinetics of each channel. Our data suggest that problems encountered when artificially stimulating neurons such as cessation in firing at high frequencies, or “fading,” may be attributed to K V -channel activation." @default.
• W2588827064 created "2017-02-24" @default.
• W2588827064 creator A5003879713 @default.
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• W2588827064 date "2017-05-01" @default.
• W2588827064 modified "2023-09-25" @default.
• W2588827064 title "Differential effect of brief electrical stimulation on voltage-gated potassium channels" @default.
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• W2588827064 doi "https://doi.org/10.1152/jn.00915.2016" @default.
• W2588827064 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5411463" @default.
• W2588827064 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28202576" @default.
• W2588827064 hasPublicationYear "2017" @default.
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