FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588841610> ?p ?o ?g. }

• W2588841610 endingPage "396" @default.
• W2588841610 startingPage "385" @default.
• W2588841610 abstract "Converging evidence supported that melamine could impair learning and memory and hippocampal function by mechanisms as yet unknown. The aim of this study was to obtain the first clues of how melamine affected spatial cognition, and how it may act on hippocampal function to modulate plasticity. Morris water maze test was used to probe spatial learning and memory. Pharmacological approaches were employed to modulate NMDAR and AMPAR-dependent long-term synaptic plasticity of rats' hippocampal CA1 region. Both systemic and intrahippocampal application of melamine impaired the formation of long-term spatial memory, particularly consolidation memory. The reduced expression of NMDA-NR1 and -NR2B subunits, but not AMPAR subunits, was presented. Meanwhile melamine inhibited inductions of long-term potentiation (LTP) and long-term depression (LTD) via mediating NMDARs. Notably, the specific role of hippocampal CA1 LTD in regulation of spatial consolidation has been observed in normal physiology. Moreover, the prevention of inhibited hippocampal CA1 LTD but not LTP could rescue the disruption of long-term spatial memory of the melamine-treated rats. Taken together, our findings suggested that acute melamine exposure impaired spatial memory consolidation via disrupting hippocampal NMDAR-dependent LTD. This provided an important insight into the neurophysiology of melamine-related and other psychiatric disorders." @default.
• W2588841610 created "2017-02-24" @default.
• W2588841610 creator A5014867897 @default.
• W2588841610 creator A5026567678 @default.
• W2588841610 date "2017-02-16" @default.
• W2588841610 modified "2023-10-17" @default.
• W2588841610 title "Acute Melamine Affects Spatial Memory Consolidation via Inhibiting Hippocampal NMDAR-Dependent LTD in Rats" @default.
• W2588841610 cites W126551111 @default.
• W2588841610 cites W1724698019 @default.
• W2588841610 cites W1965634284 @default.
• W2588841610 cites W1968024448 @default.
• W2588841610 cites W1969781703 @default.
• W2588841610 cites W1971110401 @default.
• W2588841610 cites W1973868111 @default.
• W2588841610 cites W1981114447 @default.
• W2588841610 cites W1991148764 @default.
• W2588841610 cites W1996231904 @default.
• W2588841610 cites W1998030276 @default.
• W2588841610 cites W1998071479 @default.
• W2588841610 cites W2002764325 @default.
• W2588841610 cites W2006440916 @default.
• W2588841610 cites W2007632450 @default.
• W2588841610 cites W2007836515 @default.
• W2588841610 cites W2012038403 @default.
• W2588841610 cites W2018784755 @default.
• W2588841610 cites W2025474716 @default.
• W2588841610 cites W2027685064 @default.
• W2588841610 cites W2034048630 @default.
• W2588841610 cites W2039025948 @default.
• W2588841610 cites W2042656945 @default.
• W2588841610 cites W2044172342 @default.
• W2588841610 cites W2045669174 @default.
• W2588841610 cites W2050066016 @default.
• W2588841610 cites W2060636356 @default.
• W2588841610 cites W2066605983 @default.
• W2588841610 cites W2073222688 @default.
• W2588841610 cites W2077725463 @default.
• W2588841610 cites W2078009625 @default.
• W2588841610 cites W2078046592 @default.
• W2588841610 cites W2079302576 @default.
• W2588841610 cites W2082725131 @default.
• W2588841610 cites W2087398371 @default.
• W2588841610 cites W2098743881 @default.
• W2588841610 cites W2109909801 @default.
• W2588841610 cites W2111681468 @default.
• W2588841610 cites W2115253295 @default.
• W2588841610 cites W2120605643 @default.
• W2588841610 cites W2125085972 @default.
• W2588841610 cites W2126320773 @default.
• W2588841610 cites W2128574573 @default.
• W2588841610 cites W2132806170 @default.
• W2588841610 cites W2134527764 @default.
• W2588841610 cites W2141412827 @default.
• W2588841610 cites W2141520927 @default.
• W2588841610 cites W2148605209 @default.
• W2588841610 cites W2161998020 @default.
• W2588841610 cites W2168505600 @default.
• W2588841610 cites W2170461909 @default.
• W2588841610 doi "https://doi.org/10.1093/toxsci/kfx039" @default.
• W2588841610 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28206646" @default.
• W2588841610 hasPublicationYear "2017" @default.
• W2588841610 type Work @default.
• W2588841610 sameAs 2588841610 @default.
• W2588841610 citedByCount "31" @default.
• W2588841610 countsByYear W25888416102017 @default.
• W2588841610 countsByYear W25888416102018 @default.
• W2588841610 countsByYear W25888416102019 @default.
• W2588841610 countsByYear W25888416102020 @default.
• W2588841610 countsByYear W25888416102021 @default.
• W2588841610 countsByYear W25888416102022 @default.
• W2588841610 countsByYear W25888416102023 @default.
• W2588841610 crossrefType "journal-article" @default.
• W2588841610 hasAuthorship W2588841610A5014867897 @default.
• W2588841610 hasAuthorship W2588841610A5026567678 @default.
• W2588841610 hasBestOaLocation W25888416101 @default.
• W2588841610 hasConcept C148762608 @default.
• W2588841610 hasConcept C15744967 @default.
• W2588841610 hasConcept C160268369 @default.
• W2588841610 hasConcept C169760540 @default.
• W2588841610 hasConcept C170493617 @default.
• W2588841610 hasConcept C185592680 @default.
• W2588841610 hasConcept C194973443 @default.
• W2588841610 hasConcept C25274449 @default.
• W2588841610 hasConcept C2776328245 @default.
• W2588841610 hasConcept C2781161787 @default.
• W2588841610 hasConcept C44752575 @default.
• W2588841610 hasConcept C48455012 @default.
• W2588841610 hasConcept C55493867 @default.
• W2588841610 hasConcept C61174792 @default.
• W2588841610 hasConcept C67018056 @default.
• W2588841610 hasConcept C73009533 @default.
• W2588841610 hasConcept C98229152 @default.
• W2588841610 hasConceptScore W2588841610C148762608 @default.
• W2588841610 hasConceptScore W2588841610C15744967 @default.
• W2588841610 hasConceptScore W2588841610C160268369 @default.
• W2588841610 hasConceptScore W2588841610C169760540 @default.
• W2588841610 hasConceptScore W2588841610C170493617 @default.
• W2588841610 hasConceptScore W2588841610C185592680 @default.

• next