FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588852538> ?p ?o ?g. }

• W2588852538 endingPage "491" @default.
• W2588852538 startingPage "483" @default.
• W2588852538 abstract "CER-001 comprises recombinant human apolipoprotein A-I complexed with phospholipids that mimics natural, nascent, pre-β high-density lipoprotein (HDL). We present animal model data showing dose-dependent increases in cholesterol efflux with CER-001 and its subsequent elimination by reverse lipid transport, together with inhibition of atherosclerotic plaque progression. We report the first phase I study results with CER-001 in humans, starting at 0.25 mg/kg, which is 1/80th of the safe dose (20 mg/kg) established in 4-week multiple-dose animal studies dosed every second day. Healthy volunteers, 18–55 years old with a low-density lipoprotein-cholesterol:HDL-cholesterol ratio greater than 3.0, received single intravenous escalating doses of CER-001 (0.25–45.0 mg/kg) and placebo in a double-blind randomised cross-over fashion. Subjects were followed up for 3 weeks post-dose. Assessments included adverse event monitoring, blood sampling, and clinical laboratory measurements. Thirty-two subjects were enrolled. All CER-001 doses (0.25–45 mg/kg) were safe and well tolerated, with an adverse event profile similar to placebo. Effects on clinical chemistry, haematology and coagulation parameters were comparable to placebo. No adverse effects of CER-001 on electrocardiograms were observed. No antibodies to apolipoprotein A-I were detected following single-dose administration of CER-001. Plasma apolipoprotein A-I levels increased in a dose-related manner and returned to baseline by 24 h post-dose for doses up to 10 mg/kg but remained in circulation for >72 h post-dose for doses >10 mg/kg. CER-001 caused elevations in plasma cholesterol and total and unesterified cholesterol in the HDL fraction. Mobilisation of unesterified cholesterol in the HDL fraction was seen with CER-001 at doses as low as 2 mg/kg. CER-001 is well tolerated when administered to humans as single doses up to 45 mg/kg and mobilises and eliminates cholesterol via reverse lipid transport." @default.
• W2588852538 created "2017-02-24" @default.
• W2588852538 creator A5021366259 @default.
• W2588852538 creator A5029857793 @default.
• W2588852538 creator A5073589190 @default.
• W2588852538 creator A5083830612 @default.
• W2588852538 date "2017-02-17" @default.
• W2588852538 modified "2023-10-09" @default.
• W2588852538 title "Development of CER-001: Preclinical Dose Selection Through to Phase I Clinical Findings" @default.
• W2588852538 cites W1563298486 @default.
• W2588852538 cites W2007268251 @default.
• W2588852538 cites W2024131238 @default.
• W2588852538 cites W2044341624 @default.
• W2588852538 cites W2095507444 @default.
• W2588852538 cites W2124209549 @default.
• W2588852538 cites W2126147349 @default.
• W2588852538 cites W2185025112 @default.
• W2588852538 cites W2320090292 @default.
• W2588852538 cites W2405835316 @default.
• W2588852538 cites W2604069439 @default.
• W2588852538 cites W2942956196 @default.
• W2588852538 cites W93908262 @default.
• W2588852538 doi "https://doi.org/10.1007/s40261-017-0506-3" @default.
• W2588852538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5394142" @default.
• W2588852538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28213743" @default.
• W2588852538 hasPublicationYear "2017" @default.
• W2588852538 type Work @default.
• W2588852538 sameAs 2588852538 @default.
• W2588852538 citedByCount "24" @default.
• W2588852538 countsByYear W25888525382017 @default.
• W2588852538 countsByYear W25888525382018 @default.
• W2588852538 countsByYear W25888525382019 @default.
• W2588852538 countsByYear W25888525382020 @default.
• W2588852538 countsByYear W25888525382021 @default.
• W2588852538 countsByYear W25888525382022 @default.
• W2588852538 countsByYear W25888525382023 @default.
• W2588852538 crossrefType "journal-article" @default.
• W2588852538 hasAuthorship W2588852538A5021366259 @default.
• W2588852538 hasAuthorship W2588852538A5029857793 @default.
• W2588852538 hasAuthorship W2588852538A5073589190 @default.
• W2588852538 hasAuthorship W2588852538A5083830612 @default.
• W2588852538 hasBestOaLocation W25888525381 @default.
• W2588852538 hasConcept C126322002 @default.
• W2588852538 hasConcept C134018914 @default.
• W2588852538 hasConcept C142724271 @default.
• W2588852538 hasConcept C194409129 @default.
• W2588852538 hasConcept C197934379 @default.
• W2588852538 hasConcept C204787440 @default.
• W2588852538 hasConcept C27081682 @default.
• W2588852538 hasConcept C2778163477 @default.
• W2588852538 hasConcept C2780072125 @default.
• W2588852538 hasConcept C535046627 @default.
• W2588852538 hasConcept C62746215 @default.
• W2588852538 hasConcept C71924100 @default.
• W2588852538 hasConcept C90924648 @default.
• W2588852538 hasConcept C98274493 @default.
• W2588852538 hasConceptScore W2588852538C126322002 @default.
• W2588852538 hasConceptScore W2588852538C134018914 @default.
• W2588852538 hasConceptScore W2588852538C142724271 @default.
• W2588852538 hasConceptScore W2588852538C194409129 @default.
• W2588852538 hasConceptScore W2588852538C197934379 @default.
• W2588852538 hasConceptScore W2588852538C204787440 @default.
• W2588852538 hasConceptScore W2588852538C27081682 @default.
• W2588852538 hasConceptScore W2588852538C2778163477 @default.
• W2588852538 hasConceptScore W2588852538C2780072125 @default.
• W2588852538 hasConceptScore W2588852538C535046627 @default.
• W2588852538 hasConceptScore W2588852538C62746215 @default.
• W2588852538 hasConceptScore W2588852538C71924100 @default.
• W2588852538 hasConceptScore W2588852538C90924648 @default.
• W2588852538 hasConceptScore W2588852538C98274493 @default.
• W2588852538 hasIssue "5" @default.
• W2588852538 hasLocation W25888525381 @default.
• W2588852538 hasLocation W25888525382 @default.
• W2588852538 hasLocation W25888525383 @default.
• W2588852538 hasLocation W25888525384 @default.
• W2588852538 hasOpenAccess W2588852538 @default.
• W2588852538 hasPrimaryLocation W25888525381 @default.
• W2588852538 hasRelatedWork W1966967166 @default.
• W2588852538 hasRelatedWork W1981345773 @default.
• W2588852538 hasRelatedWork W1999568358 @default.
• W2588852538 hasRelatedWork W2025648868 @default.
• W2588852538 hasRelatedWork W2026539275 @default.
• W2588852538 hasRelatedWork W2035331946 @default.
• W2588852538 hasRelatedWork W2072880852 @default.
• W2588852538 hasRelatedWork W2117255531 @default.
• W2588852538 hasRelatedWork W2418228134 @default.
• W2588852538 hasRelatedWork W2495016602 @default.
• W2588852538 hasVolume "37" @default.
• W2588852538 isParatext "false" @default.
• W2588852538 isRetracted "false" @default.
• W2588852538 magId "2588852538" @default.
• W2588852538 workType "article" @default.