FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588858044> ?p ?o ?g. }

• W2588858044 abstract "ABSTRACT Enterococcus faecium has emerged as a major opportunistic pathogen for 2 decades with the spread of hospital-adapted multidrug-resistant clones. As members of the intestinal microbiota, they are subjected to numerous bacterial stresses, including antibiotics at subinhibitory concentrations (SICs). Since fluoroquinolones are extensively prescribed, SICs are very likely to occur in vivo , with potential effects on bacterial metabolism with subsequent modulation of opportunistic traits. The aim of this study was to evaluate globally the impact of SICs of ciprofloxacin on antimicrobial resistance and pathogenicity of E. faecium . Transcriptomic analysis was performed by RNA sequencing (RNA-seq) (HiSeq 2500; Illumina) using the vanB -positive reference strain E. faecium Aus0004 in the absence or presence of ciprofloxacin SIC (0.38 mg/liter, i.e., 1/8 of the MIC). Several genetic and phenotypic tests were used for validation. In the presence of ciprofloxacin SIC, 196 genes were significantly induced, whereas 286 genes were significantly repressed, meaning that 16.8% of the E. faecium genome was altered. Among upregulated genes, EFAU004_02294 (fold change, 14.3) encoded a protein (Qnr of E. faecium [EfmQnr]) homologue of Qnr proteins involved in quinolone resistance in Gram-negative bacilli. Its implication in intrinsic and adaptive fluoroquinolone (FQ) resistance in E. faecium was experimentally ascertained. Moreover, EFAU004_02292, coding for the collagen adhesin Acm, was also induced by the SIC of ciprofloxacin (fold change, 8.2), and higher adhesion capabilities were demonstrated phenotypically. Both EfmQnr and Acm determinants may play an important role in the transition from a commensal to a pathogenic state of E. faecium that resides in the gut of patients receiving fluoroquinolone therapy." @default.
• W2588858044 created "2017-02-24" @default.
• W2588858044 creator A5007052582 @default.
• W2588858044 creator A5024221823 @default.
• W2588858044 creator A5029038074 @default.
• W2588858044 creator A5045284418 @default.
• W2588858044 creator A5058216596 @default.
• W2588858044 creator A5071463737 @default.
• W2588858044 creator A5084427308 @default.
• W2588858044 creator A5087818802 @default.
• W2588858044 date "2017-05-01" @default.
• W2588858044 modified "2023-10-15" @default.
• W2588858044 title "Subinhibitory Concentrations of Ciprofloxacin Enhance Antimicrobial Resistance and Pathogenicity of Enterococcus faecium" @default.
• W2588858044 cites W1781996060 @default.
• W2588858044 cites W1932438771 @default.
• W2588858044 cites W1965143457 @default.
• W2588858044 cites W1965715358 @default.
• W2588858044 cites W1976667730 @default.
• W2588858044 cites W1979573684 @default.
• W2588858044 cites W1990152860 @default.
• W2588858044 cites W1991634127 @default.
• W2588858044 cites W1993205284 @default.
• W2588858044 cites W1996499165 @default.
• W2588858044 cites W2003660859 @default.
• W2588858044 cites W2006805047 @default.
• W2588858044 cites W2012648888 @default.
• W2588858044 cites W2029063045 @default.
• W2588858044 cites W2041932561 @default.
• W2588858044 cites W2045511565 @default.
• W2588858044 cites W2047160440 @default.
• W2588858044 cites W2053000830 @default.
• W2588858044 cites W2056627860 @default.
• W2588858044 cites W2065626701 @default.
• W2588858044 cites W2075969575 @default.
• W2588858044 cites W2080766116 @default.
• W2588858044 cites W2081437959 @default.
• W2588858044 cites W2083110628 @default.
• W2588858044 cites W2098992986 @default.
• W2588858044 cites W2102366293 @default.
• W2588858044 cites W2102619694 @default.
• W2588858044 cites W2108779461 @default.
• W2588858044 cites W2113711383 @default.
• W2588858044 cites W2115043517 @default.
• W2588858044 cites W2115486016 @default.
• W2588858044 cites W2115823582 @default.
• W2588858044 cites W2121707816 @default.
• W2588858044 cites W2123543206 @default.
• W2588858044 cites W2125376579 @default.
• W2588858044 cites W2128786685 @default.
• W2588858044 cites W2137167776 @default.
• W2588858044 cites W2139470960 @default.
• W2588858044 cites W2148583858 @default.
• W2588858044 cites W2149265860 @default.
• W2588858044 cites W2152239989 @default.
• W2588858044 cites W2158728493 @default.
• W2588858044 cites W2158804744 @default.
• W2588858044 cites W2161752106 @default.
• W2588858044 cites W2163479743 @default.
• W2588858044 cites W2264366671 @default.
• W2588858044 cites W2331292664 @default.
• W2588858044 doi "https://doi.org/10.1128/aac.02763-16" @default.
• W2588858044 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5404537" @default.
• W2588858044 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28193670" @default.
• W2588858044 hasPublicationYear "2017" @default.
• W2588858044 type Work @default.
• W2588858044 sameAs 2588858044 @default.
• W2588858044 citedByCount "26" @default.
• W2588858044 countsByYear W25888580442017 @default.
• W2588858044 countsByYear W25888580442018 @default.
• W2588858044 countsByYear W25888580442019 @default.
• W2588858044 countsByYear W25888580442020 @default.
• W2588858044 countsByYear W25888580442021 @default.
• W2588858044 countsByYear W25888580442022 @default.
• W2588858044 countsByYear W25888580442023 @default.
• W2588858044 crossrefType "journal-article" @default.
• W2588858044 hasAuthorship W2588858044A5007052582 @default.
• W2588858044 hasAuthorship W2588858044A5024221823 @default.
• W2588858044 hasAuthorship W2588858044A5029038074 @default.
• W2588858044 hasAuthorship W2588858044A5045284418 @default.
• W2588858044 hasAuthorship W2588858044A5058216596 @default.
• W2588858044 hasAuthorship W2588858044A5071463737 @default.
• W2588858044 hasAuthorship W2588858044A5084427308 @default.
• W2588858044 hasAuthorship W2588858044A5087818802 @default.
• W2588858044 hasBestOaLocation W25888580441 @default.
• W2588858044 hasConcept C133936738 @default.
• W2588858044 hasConcept C2777677444 @default.
• W2588858044 hasConcept C2778512257 @default.
• W2588858044 hasConcept C4937899 @default.
• W2588858044 hasConcept C501593827 @default.
• W2588858044 hasConcept C86803240 @default.
• W2588858044 hasConcept C89423630 @default.
• W2588858044 hasConcept C94665300 @default.
• W2588858044 hasConceptScore W2588858044C133936738 @default.
• W2588858044 hasConceptScore W2588858044C2777677444 @default.
• W2588858044 hasConceptScore W2588858044C2778512257 @default.
• W2588858044 hasConceptScore W2588858044C4937899 @default.
• W2588858044 hasConceptScore W2588858044C501593827 @default.
• W2588858044 hasConceptScore W2588858044C86803240 @default.
• W2588858044 hasConceptScore W2588858044C89423630 @default.
• W2588858044 hasConceptScore W2588858044C94665300 @default.

• next