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- W2588866236 abstract "Background: Diffuse large B-cell lymphoma (DLBCL) and mucosa-associated lymphoid tissue lymphoma occupy the majority of malignant lymphoma of the thyroid gland, and the frequency of T-cell lymphoma is very rare. We experienced a case of peripheral T-cell lymphoma (PTCL) of the thyroid gland with Hashimoto's disease and report this with literature review. Case: A 71-year-old woman was diagnosed as subclinical hypothyroidism with an autoantibody. She began to take oral levothyroxine due to progressive diffuse goiter and an elevated serum level of thyroid stimulating hormone (TSH) and the dose was increased up to 100 µg/day. Because her white blood cell count increased to 52,600, bone marrow aspiration was performed and it revealed T-cell lymphoma involvement. After visiting our hospital, CT and PET-CT showed huge diffuse goiter, liver and multiple pulmonary lesions and she was diagnosed as PTCL by core needle biopsy of the thyroid gland. She was hospitalized and underwent 80% dose of cyclophosphamide/adriamycin/vincristine/PSL (CHOP) therapy. The size of thyroid gland was decreased and she experienced Grade 4 neutropenia. She was discharged and is still under total eight-course chemotherapy. After sixth cycle of CHOP therapy, CT showed remaining diffuse goiter due to Hashimoto's disease. Serum TSH level is lowered at the same dose of levothyroxine. Discussion: There are some case reports but no review articles in PTCL of the thyroid gland. Most of them have a background of Hashimoto's disease. Yoshida et al reported six cases and that tumor cells were positive for CD3, CD4 and CXCR3, suggesting they are originated from type-1 helper T cell, and that 10-year survival rate was 83% (Br J Haematol, 2013, 161, 214-223). As PTCL usually has worse prognosis than DLBCL, this good prognosis seems interesting. This type of lymphoma needs more case accumulation and analysis to be a new category of disease classification." @default.
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- W2588866236 date "2016-11-01" @default.
- W2588866236 modified "2023-09-29" @default.
- W2588866236 title "A case of peripheral T-cell lymphoma of the thyroid gland with Hashimoto's disease" @default.
- W2588866236 doi "https://doi.org/10.1093/annonc/mdw524.012" @default.
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