FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588879310> ?p ?o ?g. }

• W2588879310 abstract "Idiopathic pulmonary fibrosis (IPF) is a progressive disease that causes unremitting deposition of extracellular matrix proteins, thus resulting in distortion of the pulmonary architecture and impaired gas exchange. Associated with high morbidity and mortality, IPF is generally refractory to current pharmacological therapies. Lefty A, a potent inhibitor of transforming growth factor-β signaling, has been shown to have promising antifibrotic ability in vitro for the treatment of renal fibrosis and other potential organ fibroses. Here, we determined whether Lefty A can attenuate bleomycin (BLM)-induced pulmonary fibrosis in vivo based on a novel therapeutic strategy where human embryonic kidney 293 (HEK293) cells are genetically engineered with the Lefty A-associated GFP gene. The engineered HEK293 cells were encapsulated in alginate microcapsules and then subcutaneously implanted in ICR mice that had 1 wk earlier been intratracheally administered BLM to induce pulmonary fibrosis. The severity of fibrosis in lung tissue was assessed using pathological morphology and collagen expression to examine the effect of Lefty A released from the microencapsulated cells. The engineered HEK293 cells with Lefty A significantly reduced the expression of connective tissue growth factor and collagen type I mRNA, lessened the morphological fibrotic effects induced by BLM, and increased the expression of matrix metalloproteinase-9. This illustrates that engineered HEK293 cells with Lefty A can attenuate pulmonary fibrosis in vivo, thus providing a novel method to treat human pulmonary fibrotic disease and other organ fibroses." @default.
• W2588879310 created "2017-02-24" @default.
• W2588879310 creator A5000063159 @default.
• W2588879310 creator A5005966979 @default.
• W2588879310 creator A5022504253 @default.
• W2588879310 creator A5030554560 @default.
• W2588879310 creator A5036431784 @default.
• W2588879310 creator A5036955339 @default.
• W2588879310 creator A5047170729 @default.
• W2588879310 creator A5054194650 @default.
• W2588879310 creator A5058609561 @default.
• W2588879310 date "2017-05-01" @default.
• W2588879310 modified "2023-09-24" @default.
• W2588879310 title "Microencapsulation of Lefty-secreting engineered cells for pulmonary fibrosis therapy in mice" @default.
• W2588879310 cites W1918921238 @default.
• W2588879310 cites W1936440991 @default.
• W2588879310 cites W1963668596 @default.
• W2588879310 cites W1968649526 @default.
• W2588879310 cites W1983366269 @default.
• W2588879310 cites W1998274991 @default.
• W2588879310 cites W1999644843 @default.
• W2588879310 cites W2009740683 @default.
• W2588879310 cites W2011508078 @default.
• W2588879310 cites W2021856189 @default.
• W2588879310 cites W2033084566 @default.
• W2588879310 cites W2035131862 @default.
• W2588879310 cites W2036430467 @default.
• W2588879310 cites W2036552662 @default.
• W2588879310 cites W2044788332 @default.
• W2588879310 cites W2047310826 @default.
• W2588879310 cites W2057824268 @default.
• W2588879310 cites W2060953954 @default.
• W2588879310 cites W2064307892 @default.
• W2588879310 cites W2065059030 @default.
• W2588879310 cites W2079311676 @default.
• W2588879310 cites W2100240870 @default.
• W2588879310 cites W2100970629 @default.
• W2588879310 cites W2102027213 @default.
• W2588879310 cites W2108933003 @default.
• W2588879310 cites W2114054457 @default.
• W2588879310 cites W2115648956 @default.
• W2588879310 cites W2115753350 @default.
• W2588879310 cites W2124056092 @default.
• W2588879310 cites W2129413765 @default.
• W2588879310 cites W2131176598 @default.
• W2588879310 cites W2138871107 @default.
• W2588879310 cites W2140366108 @default.
• W2588879310 cites W2144921016 @default.
• W2588879310 cites W2148913003 @default.
• W2588879310 cites W2161820725 @default.
• W2588879310 cites W2167211373 @default.
• W2588879310 cites W2168666423 @default.
• W2588879310 cites W2170331002 @default.
• W2588879310 cites W2218118000 @default.
• W2588879310 cites W2265806176 @default.
• W2588879310 cites W2292742428 @default.
• W2588879310 cites W2332380954 @default.
• W2588879310 cites W2342846323 @default.
• W2588879310 cites W2400396400 @default.
• W2588879310 cites W4243733521 @default.
• W2588879310 cites W4255779404 @default.
• W2588879310 doi "https://doi.org/10.1152/ajplung.00295.2016" @default.
• W2588879310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28213468" @default.
• W2588879310 hasPublicationYear "2017" @default.
• W2588879310 type Work @default.
• W2588879310 sameAs 2588879310 @default.
• W2588879310 citedByCount "2" @default.
• W2588879310 countsByYear W25888793102021 @default.
• W2588879310 crossrefType "journal-article" @default.
• W2588879310 hasAuthorship W2588879310A5000063159 @default.
• W2588879310 hasAuthorship W2588879310A5005966979 @default.
• W2588879310 hasAuthorship W2588879310A5022504253 @default.
• W2588879310 hasAuthorship W2588879310A5030554560 @default.
• W2588879310 hasAuthorship W2588879310A5036431784 @default.
• W2588879310 hasAuthorship W2588879310A5036955339 @default.
• W2588879310 hasAuthorship W2588879310A5047170729 @default.
• W2588879310 hasAuthorship W2588879310A5054194650 @default.
• W2588879310 hasAuthorship W2588879310A5058609561 @default.
• W2588879310 hasBestOaLocation W25888793101 @default.
• W2588879310 hasConcept C126322002 @default.
• W2588879310 hasConcept C142724271 @default.
• W2588879310 hasConcept C189165786 @default.
• W2588879310 hasConcept C2777714996 @default.
• W2588879310 hasConcept C2778341716 @default.
• W2588879310 hasConcept C2780559512 @default.
• W2588879310 hasConcept C2781244666 @default.
• W2588879310 hasConcept C502942594 @default.
• W2588879310 hasConcept C71924100 @default.
• W2588879310 hasConcept C86803240 @default.
• W2588879310 hasConcept C95444343 @default.
• W2588879310 hasConceptScore W2588879310C126322002 @default.
• W2588879310 hasConceptScore W2588879310C142724271 @default.
• W2588879310 hasConceptScore W2588879310C189165786 @default.
• W2588879310 hasConceptScore W2588879310C2777714996 @default.
• W2588879310 hasConceptScore W2588879310C2778341716 @default.
• W2588879310 hasConceptScore W2588879310C2780559512 @default.
• W2588879310 hasConceptScore W2588879310C2781244666 @default.
• W2588879310 hasConceptScore W2588879310C502942594 @default.
• W2588879310 hasConceptScore W2588879310C71924100 @default.
• W2588879310 hasConceptScore W2588879310C86803240 @default.

• next