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• W2588892617 abstract "Thiourea derivatives demonstrate potent cytotoxic activity against various leukemias and many tumor cell lines. In our previous study, the combination of thiourea and phosphonate has been proven as an effective strategy for developing antitumor agents. Herein, we synthesized and evaluated a series of novel chiral dipeptide thioureas containing an α-aminophosphonate moiety as antitumor agents. Finally, we developed novel dipeptide thioureas 11d and 11f that showed comparable inhibition with that of Cisplatin against BGC-823 and A-549 cells, respectively." @default.
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• W2588892617 date "2017-02-16" @default.
• W2588892617 modified "2023-10-14" @default.
• W2588892617 title "Synthesis and Antitumor Activities of Chiral Dipeptide Thioureas Containing an Alpha-Aminophosphonate Moiety" @default.
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• W2588892617 doi "https://doi.org/10.3390/molecules22020238" @default.
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