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- W2588894634 abstract "Abcisic acid (ABA) is a natural phytohormone and PPARgamma agonist that significantly improves insulin sensitivity in db/db mice. Though it has become clear that obesity is associated with macrophage infiltration into white adipose tissue (WAT), the phenotype of adipose tissue macrophages (ATMs) and the mechanisms by which insulin- sensitizing compounds modulate their infiltration remains unknown. We used a loss-of- function approach to investigate whether ABA ameliorates insulin resistance through a mechanism dependent on immune cell PPARgamma. We characterized two phenotypically distinct ATM subsets in db/db mice based on their surface expression of F4/80. The F4/80 ATMs were more abundant and expressed greater concentrations of chemokine receptor 2 (CCR2) and CCR5 when compared to F4/80 ATMs. ABA significantly decreased CCR2F4/80 infiltration into WAT and suppressed monocyte chemoattractant protein-1 (MCP-1) expression in WAT and plasma. Furthermore, the deficiency of PPARgamma in immune cells, including macrophages, impaired the ability of ABA to suppress infiltration of F4/80 ATMs into WAT, repress WAT MCP-1 expression and improve glucose tolerance. We provide molecular evidence in vivo demonstrating that ABA improves insulin sensitivity and obesity-related inflammation by inhibiting MCP-1 expression and F4/80 ATM infiltration through a PPARgamma- dependent mechanism." @default.
- W2588894634 created "2017-02-24" @default.
- W2588894634 creator A5084985722 @default.
- W2588894634 date "2007-10-19" @default.
- W2588894634 modified "2023-09-26" @default.
- W2588894634 title "Abscisic acid ameliorates glucose tolerance and obesity-induced inflammation" @default.
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