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• W2588895554 abstract "Campylobacter jejuni is recognized as one of the most common causes of food-borne gastrointestinal illness worldwide, resulting in a self-limiting dysentery in developed countries. However, it is increasingly gaining attention due to its association with postinfectious complications such as Guillain-Barré Syndrome and recently recognized importance in early childhood diarrhea in developing countries. We hypothesize that the inflammation mediated by C. jejuni infection causes environmental enteric dysfunction, and with contribution from diet and the host, microbiome may be responsible for growth faltering in children and developmental disability.Diet plays a major role in the impact of C. jejuni infection, both by availability of micronutrients for the bacteria and host as well as shaping the microbiome that affords resistance. Early childhood repeated exposure to the bacterium results in inflammation that affords long-term immunity but, in the short term, can lead to malabsorption, oral vaccine failure, cognitive delay and increased under-5 mortality.As interest in C. jejuni increases, our understanding of its virulence mechanisms has improved. However, much work remains to be done to fully understand the implications of immune-mediated inflammation and its potential role in diseases such as environmental enteric dysfunction." @default.
• W2588895554 created "2017-02-24" @default.
• W2588895554 creator A5050404191 @default.
• W2588895554 creator A5068162558 @default.
• W2588895554 date "2017-06-01" @default.
• W2588895554 modified "2023-09-26" @default.
• W2588895554 title "Campylobacter jejuni and associated immune mechanisms" @default.
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• W2588895554 doi "https://doi.org/10.1097/qco.0000000000000364" @default.
• W2588895554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5560167" @default.
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• W2588895554 hasPublicationYear "2017" @default.
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