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- W2588895577 abstract "Background: Molecular characterization of low grade gliomas (LGG) has improved in recent years and is essential for diagnosis and treatment of these diseases. Moreover, clinical factors, such as age and the extent of surgery retain a prognostic role in LGG that were assessed for IDH1/2, 1p/19q codeletion, and MGMT methylation status. Methods: we retrospectively evaluated all adult LGG patients (pts) from our data warehouse who received surgery and had sufficient tissue to assess biomarkers characterization. IDH1/2 assessment was performed on formalin-fixed paraffin-embedded samples by PCR, MGMT by methylation specific PCR, 1p/19 codeletion by FISH. Results: 198 consecutive LGG were included. The median age was 38 (range:18–72). Median follow up was 74.0 months, 109 pts (55.1%) were <40 years of age; 26 pts (13.1%) underwent biopsy, 119 pts (60.1%) partial resection, 53 pts (26.8%) complete resection. Twenty-eight pts (14.1%) were considered low risk (<40 years with complete resection). IDH1/2 mutation was found in 79.8% of pts. 1p/19q codeletion was found in 41.4% of pts, MGMT methylation in 57.1% of pts. Median survival in low risk patients was 211.0 months (95%CI: 190.4–231.6) and was 145.3 months (95%CI: 108.5–182.2) in high risk patients (P = 0.006). Median survival for patients with IDH1/2 mutation was 159 months (95%CI: 103.3–214.7) and was 87.9 months in patients IDH1/2 wild type (95%CI: 61.1–114.6, P < 0.001). Multivariate analysis showed that clinical risk (P = 0.006), IDH1/2 mutation (P < 0.001) and 1p/19q codeletion (P = 0.03) were significantly correlated with overall survival. MGMT methylation was not significant. Conclusions: Molecular characteristic of LGG define the prognosis of these tumors. Moreover, clinical risk assessment retains a role even in the era of molecular characterization." @default.
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- W2588895577 date "2016-09-01" @default.
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- W2588895577 title "The role of clinical risk in Low Grade Glioma patients in the era of genomic medicine: a GICNO study" @default.
- W2588895577 doi "https://doi.org/10.1093/annonc/mdw345.03" @default.
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