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- W2588896857 abstract "Background Prefrontal and temporoparietal repetitive transcranial magnetic stimulation (rTMS) in chronic tinnitus showed significant but only moderate effectiveness with high inter-individual variability in treatment response. This study was designed to proof the feasibility of an individualized fronto-temporal rTMS paradigm. Methods During the first session of our standard two-week rTMS setting we applied different protocols to the left and right temporoparietal and dorsolateral prefrontal cortex (DLPFC) in 25 tinnitus patients. In each protocol 200 pulses (except for 1 Hz frequency containing 50 pulses) were applied at frequencies of 1 Hz, 5 Hz, 10 Hz, 20 Hz, cTBS, sham (continuous theta burst stimulation). Patients reporting immediate tinnitus reduction were treated in an individualized manner applying a combined protocol consisting of the most effective frontal and the most effective temporoparietal stimulation protocol. Those patients who did not improve after the test session were treated with a standard fronto-temporoparietal protocol. Results Almost half of the patients (12 out of 25) reported immediate tinnitus reduction in the test session. In this group the mean pre-to-post-treatment amelioration in the tinnitus questionnaire was 8.6 ± 8.9 whereas the improvement was only 1.5 ± 8.5 in those patients who did not respond to the test session. Treatment outcome remained stable over a follow-up period of ten weeks. Discussion Individualized rTMS was shown to be feasible and effective in chronic tinnitus and might provide a basis for a “tailored” application of rTMS in tinnitus and other neuropsychiatric disorders." @default.
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- W2588896857 date "2017-03-01" @default.
- W2588896857 modified "2023-09-27" @default.
- W2588896857 title "P057 Individualized rTMS: a proof-of-concept study in chronic tinnitus" @default.
- W2588896857 doi "https://doi.org/10.1016/j.clinph.2016.10.182" @default.
- W2588896857 hasPublicationYear "2017" @default.
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