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- W2588907879 abstract "Background: Hypercalcemia is often associated with malignant tumors. Eighty percent of cases with hypercalcemia are caused by overproduced parathyroid hormone-related protein (PTHrP) in tumor cells (humoral hypercalcemia of malignancy; HHM). HHM has hardly been in GIST. Few case reports of GIST with increased serum level of PTHrP have been reported. Case: A 73-year-old Japanese male, with a background history of hypothyroidism and gastric cancer, had underwent subtotal gastrectomy. However, follow-up examination revealed the peritoneal dissemination, definitely diagnosed as KIT-positive GIST of small intestinal origin. The patient had been treated with tyrosine kinase inhibitors; imatinib for 2 years 2 months, sunitinib for 1 year 10 months and regorafenib, successively up to progressive disease (PD). On regorafenib treatment day 14, the patient developed erythema multiforme type drug eruption. After recovery from the allergic reaction, he voluntarily participated in an industry-initiated clinical study at our hospital. Since before the study drug administration, the serum calcium level had gradually increased. To improve the hypercalcemia, elcatonin, isotonic saline, zoledronic acid and denosumab were stepwisely administered. Hence, we found the serum PTHrP level was elevated (38.9pmol/l, reference value: <1.1 pmol/l). We therefore diagnosed his illness as HHM. There was no evidence of either recurrence of the early gastric cancer or bone metastases or HTLV-I infection. After 4 months from termination of regorafenib administration, he died of malignant tumor progression. Conclusion: We report herein a rare case of HHM associated with GIST with increased serum level of PTHrP. Our intensive literature search revealed only one prior report on a similar case." @default.
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- W2588907879 date "2016-11-01" @default.
- W2588907879 modified "2023-09-26" @default.
- W2588907879 title "A Case of gastrointestinal stromal tumor complicated by hypercalcemia induced by parathyroid hormone-related protein" @default.
- W2588907879 doi "https://doi.org/10.1093/annonc/mdw524.011" @default.
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