Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588918025> ?p ?o ?g. }
- W2588918025 endingPage "3312" @default.
- W2588918025 startingPage "3305" @default.
- W2588918025 abstract "Platelet-activated serum (PAS) was collected from rabbits. This contains high concentrations of growth factors, including vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF)-BB, and transforming growth factor-beta (TGF-β). PAS was injected into the knee joints of Japanese White rabbits subjected to anterior cruciate ligament transection (ACL-T) to investigate its therapeutic effects on articular cartilage. The effect of Avastin (an anti-VEGF monoclonal antibody) on VEGF expression was also investigated. The levels of VEGF, PDGF-BB, and TGF-β in PAS, platelet-rich plasma (PRP) and autologous serum from untreated rabbits were analysed by enzyme-linked immunosorbent assays. The samples (n = 24 rabbits) were divided into control (C), PAS (S), Avastin (A) and PAS + Avastin (S + A) treatment groups. Intra-articular injections were administered weekly for 7 weeks after ACL-T, during which the weight distribution ratios of the damaged limbs were evaluated. Histological evaluation was performed 12 weeks after ACL-T using Mankin score. The VEGF, PDGF-BB and TGF-β expression levels were significantly higher (P < 0.05) in the PAS than in the PRP or autologous serum samples. The weight distribution ratios of damaged limbs improved significantly after ACL-T in all treatment groups (P < 0.05). The proximal medial, distal medial and lateral aspects of joints in the treatment groups showed significant differences in Mankin scores compared with controls (P < 0.05). The damaged limb weight distribution ratios, Mankin scores and articular cartilage structure did not differ significantly among the three treatment groups, which all showed significant improvements in structure compared with controls. Copyright © 2017 John Wiley & Sons, Ltd." @default.
- W2588918025 created "2017-02-24" @default.
- W2588918025 creator A5007036600 @default.
- W2588918025 creator A5021209820 @default.
- W2588918025 creator A5023058088 @default.
- W2588918025 creator A5028529686 @default.
- W2588918025 creator A5037179163 @default.
- W2588918025 creator A5046565682 @default.
- W2588918025 creator A5073654980 @default.
- W2588918025 creator A5079636148 @default.
- W2588918025 date "2017-02-14" @default.
- W2588918025 modified "2023-09-24" @default.
- W2588918025 title "Platelet-activated serum might have a therapeutic effect on damaged articular cartilage" @default.
- W2588918025 cites W1566331874 @default.
- W2588918025 cites W1973771232 @default.
- W2588918025 cites W1975890825 @default.
- W2588918025 cites W1978511310 @default.
- W2588918025 cites W1989658278 @default.
- W2588918025 cites W1991450823 @default.
- W2588918025 cites W2002554431 @default.
- W2588918025 cites W2004191289 @default.
- W2588918025 cites W2006050540 @default.
- W2588918025 cites W2006113857 @default.
- W2588918025 cites W2016724821 @default.
- W2588918025 cites W2021046715 @default.
- W2588918025 cites W2030322516 @default.
- W2588918025 cites W2031760606 @default.
- W2588918025 cites W2034066410 @default.
- W2588918025 cites W2057491978 @default.
- W2588918025 cites W2064060844 @default.
- W2588918025 cites W2068864388 @default.
- W2588918025 cites W2075395189 @default.
- W2588918025 cites W2075566938 @default.
- W2588918025 cites W2096943317 @default.
- W2588918025 cites W2099204150 @default.
- W2588918025 cites W2099606884 @default.
- W2588918025 cites W2117042362 @default.
- W2588918025 cites W2118354315 @default.
- W2588918025 cites W2138312249 @default.
- W2588918025 cites W2141619324 @default.
- W2588918025 cites W2148080767 @default.
- W2588918025 cites W2149573531 @default.
- W2588918025 cites W2149781582 @default.
- W2588918025 cites W2157451902 @default.
- W2588918025 cites W2157769714 @default.
- W2588918025 cites W2159967512 @default.
- W2588918025 cites W2164434561 @default.
- W2588918025 cites W2164916690 @default.
- W2588918025 cites W2332196493 @default.
- W2588918025 cites W4292542165 @default.
- W2588918025 doi "https://doi.org/10.1002/term.2238" @default.
- W2588918025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28194878" @default.
- W2588918025 hasPublicationYear "2017" @default.
- W2588918025 type Work @default.
- W2588918025 sameAs 2588918025 @default.
- W2588918025 citedByCount "8" @default.
- W2588918025 countsByYear W25889180252018 @default.
- W2588918025 countsByYear W25889180252019 @default.
- W2588918025 countsByYear W25889180252020 @default.
- W2588918025 countsByYear W25889180252021 @default.
- W2588918025 countsByYear W25889180252022 @default.
- W2588918025 crossrefType "journal-article" @default.
- W2588918025 hasAuthorship W2588918025A5007036600 @default.
- W2588918025 hasAuthorship W2588918025A5021209820 @default.
- W2588918025 hasAuthorship W2588918025A5023058088 @default.
- W2588918025 hasAuthorship W2588918025A5028529686 @default.
- W2588918025 hasAuthorship W2588918025A5037179163 @default.
- W2588918025 hasAuthorship W2588918025A5046565682 @default.
- W2588918025 hasAuthorship W2588918025A5073654980 @default.
- W2588918025 hasAuthorship W2588918025A5079636148 @default.
- W2588918025 hasBestOaLocation W25889180251 @default.
- W2588918025 hasConcept C105702510 @default.
- W2588918025 hasConcept C118131993 @default.
- W2588918025 hasConcept C126322002 @default.
- W2588918025 hasConcept C126894567 @default.
- W2588918025 hasConcept C134018914 @default.
- W2588918025 hasConcept C141071460 @default.
- W2588918025 hasConcept C142724271 @default.
- W2588918025 hasConcept C167734588 @default.
- W2588918025 hasConcept C170493617 @default.
- W2588918025 hasConcept C180361614 @default.
- W2588918025 hasConcept C185592680 @default.
- W2588918025 hasConcept C204787440 @default.
- W2588918025 hasConcept C2775960820 @default.
- W2588918025 hasConcept C2776164576 @default.
- W2588918025 hasConcept C2777025900 @default.
- W2588918025 hasConcept C2778434673 @default.
- W2588918025 hasConcept C2780076745 @default.
- W2588918025 hasConcept C2780550940 @default.
- W2588918025 hasConcept C2781294074 @default.
- W2588918025 hasConcept C3020332539 @default.
- W2588918025 hasConcept C71924100 @default.
- W2588918025 hasConcept C89560881 @default.
- W2588918025 hasConceptScore W2588918025C105702510 @default.
- W2588918025 hasConceptScore W2588918025C118131993 @default.
- W2588918025 hasConceptScore W2588918025C126322002 @default.
- W2588918025 hasConceptScore W2588918025C126894567 @default.
- W2588918025 hasConceptScore W2588918025C134018914 @default.