FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588937877> ?p ?o ?g. }

• W2588937877 abstract "To investigate the effect of inhibitor κBα (IκBα) on severe pneumonia and explain the mechanisms of nuclear factor κB (NF-κB), the activation of NF-κB was induced in Sprague-Dawley (SD) rats infected with Klebsiella pneumoniae (K. pneumoniae). The rats were then treated with differing concentrations of IκBα protein. A histological analysis was performed to compare the lung structure prior to and following treatment, and an immunohistochemistry assay was used to detect NF-κB activity. In addition, the expression of certain inflammatory factors was detected using a protein chip assay. The severe pneumonia rat model was successfully produced and in model rats, NF-κB was activated by K. pneumoniae. Following treatment with IκBα, the activity of NF-κB was inhibited and pneumonia symptoms in model rats were alleviated. Furthermore, the expression of a number of inflammatory factors including tumor necrosis factor α (TNF-α), interleukin 6 (IL-6), interferon γ (IFN-γ) and monocyte chemoattractant protein-1 (MCP-1) were also inhibited. The current study demonstrates that NF-κB inhibition with IκBα protein therapy prevents the development of pneumonia in a K. pneumoniae rat model. The therapeutic effect is indicated by the responses of proinflammatory factors, including TNF-α, IL-6, IFN-γ and MCP-1." @default.
• W2588937877 created "2017-02-24" @default.
• W2588937877 creator A5042867325 @default.
• W2588937877 creator A5055370818 @default.
• W2588937877 creator A5056036271 @default.
• W2588937877 creator A5075724576 @default.
• W2588937877 date "2017-02-16" @default.
• W2588937877 modified "2023-09-27" @default.
• W2588937877 title "Inhibitor κBα protein therapy alleviates severe pneumonia through inhibition of nuclear factor κB" @default.
• W2588937877 cites W1527523607 @default.
• W2588937877 cites W1581220495 @default.
• W2588937877 cites W1915074145 @default.
• W2588937877 cites W1967291007 @default.
• W2588937877 cites W1990965169 @default.
• W2588937877 cites W1991905599 @default.
• W2588937877 cites W2002601205 @default.
• W2588937877 cites W2089121511 @default.
• W2588937877 cites W2096143286 @default.
• W2588937877 cites W2105896882 @default.
• W2588937877 cites W2109551620 @default.
• W2588937877 cites W2114570412 @default.
• W2588937877 cites W2116105877 @default.
• W2588937877 cites W2120952674 @default.
• W2588937877 cites W2121831811 @default.
• W2588937877 cites W2126767292 @default.
• W2588937877 cites W2129824469 @default.
• W2588937877 cites W2134768631 @default.
• W2588937877 cites W2142188564 @default.
• W2588937877 cites W2156131212 @default.
• W2588937877 cites W2159371992 @default.
• W2588937877 cites W2331176038 @default.
• W2588937877 cites W54596544 @default.
• W2588937877 doi "https://doi.org/10.3892/etm.2017.4130" @default.
• W2588937877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5377337" @default.
• W2588937877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28413484" @default.
• W2588937877 hasPublicationYear "2017" @default.
• W2588937877 type Work @default.
• W2588937877 sameAs 2588937877 @default.
• W2588937877 citedByCount "3" @default.
• W2588937877 countsByYear W25889378772018 @default.
• W2588937877 countsByYear W25889378772019 @default.
• W2588937877 crossrefType "journal-article" @default.
• W2588937877 hasAuthorship W2588937877A5042867325 @default.
• W2588937877 hasAuthorship W2588937877A5055370818 @default.
• W2588937877 hasAuthorship W2588937877A5056036271 @default.
• W2588937877 hasAuthorship W2588937877A5075724576 @default.
• W2588937877 hasBestOaLocation W25889378771 @default.
• W2588937877 hasConcept C126322002 @default.
• W2588937877 hasConcept C164027704 @default.
• W2588937877 hasConcept C17991360 @default.
• W2588937877 hasConcept C190283241 @default.
• W2588937877 hasConcept C203014093 @default.
• W2588937877 hasConcept C2776914184 @default.
• W2588937877 hasConcept C2777730290 @default.
• W2588937877 hasConcept C2777914695 @default.
• W2588937877 hasConcept C2778690821 @default.
• W2588937877 hasConcept C2779730028 @default.
• W2588937877 hasConcept C2781018059 @default.
• W2588937877 hasConcept C29537977 @default.
• W2588937877 hasConcept C502942594 @default.
• W2588937877 hasConcept C55493867 @default.
• W2588937877 hasConcept C71924100 @default.
• W2588937877 hasConcept C74172505 @default.
• W2588937877 hasConcept C86803240 @default.
• W2588937877 hasConcept C98274493 @default.
• W2588937877 hasConceptScore W2588937877C126322002 @default.
• W2588937877 hasConceptScore W2588937877C164027704 @default.
• W2588937877 hasConceptScore W2588937877C17991360 @default.
• W2588937877 hasConceptScore W2588937877C190283241 @default.
• W2588937877 hasConceptScore W2588937877C203014093 @default.
• W2588937877 hasConceptScore W2588937877C2776914184 @default.
• W2588937877 hasConceptScore W2588937877C2777730290 @default.
• W2588937877 hasConceptScore W2588937877C2777914695 @default.
• W2588937877 hasConceptScore W2588937877C2778690821 @default.
• W2588937877 hasConceptScore W2588937877C2779730028 @default.
• W2588937877 hasConceptScore W2588937877C2781018059 @default.
• W2588937877 hasConceptScore W2588937877C29537977 @default.
• W2588937877 hasConceptScore W2588937877C502942594 @default.
• W2588937877 hasConceptScore W2588937877C55493867 @default.
• W2588937877 hasConceptScore W2588937877C71924100 @default.
• W2588937877 hasConceptScore W2588937877C74172505 @default.
• W2588937877 hasConceptScore W2588937877C86803240 @default.
• W2588937877 hasConceptScore W2588937877C98274493 @default.
• W2588937877 hasLocation W25889378771 @default.
• W2588937877 hasLocation W25889378772 @default.
• W2588937877 hasLocation W25889378773 @default.
• W2588937877 hasLocation W25889378774 @default.
• W2588937877 hasOpenAccess W2588937877 @default.
• W2588937877 hasPrimaryLocation W25889378771 @default.
• W2588937877 hasRelatedWork W1541031982 @default.
• W2588937877 hasRelatedWork W1976821497 @default.
• W2588937877 hasRelatedWork W2023499824 @default.
• W2588937877 hasRelatedWork W2037231299 @default.
• W2588937877 hasRelatedWork W2124186983 @default.
• W2588937877 hasRelatedWork W2144224588 @default.
• W2588937877 hasRelatedWork W2162748264 @default.
• W2588937877 hasRelatedWork W2356296448 @default.
• W2588937877 hasRelatedWork W2887977191 @default.
• W2588937877 hasRelatedWork W4293553747 @default.
• W2588937877 isParatext "false" @default.

• next