FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2588942442> ?p ?o ?g. }

• W2588942442 abstract "Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with 50% effective concentration (EC50) values ranging from 1.4 to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. Pibrentasvir demonstrated similar activity against a panel of chimeric replicons containing HCV NS5A of genotypes 1 to 6 from clinical samples. Resistance selection studies were conducted using HCV replicon cells with NS5A from genotype 1a, 1b, 2a, 2b, 3a, 4a, 5a, or 6a at a concentration of pibrentasvir that was 10- or 100-fold over its EC50 for the respective replicon. With pibrentasvir at 10-fold over the respective EC50, only a small number of colonies (0.00015 to 0.0065% of input cells) with resistance-associated amino acid substitutions were selected in replicons containing genotype 1a, 2a, or 3a NS5A, and no viable colonies were selected in replicons containing NS5A from other genotypes. With pibrentasvir at 100-fold over the respective EC50, very few colonies (0.0002% of input cells) were selected by pibrentasvir in genotype 1a replicon cells while no colonies were selected in other replicons. Pibrentasvir is active against common resistance-conferring substitutions in HCV genotypes 1 to 6 that were identified for other NS5A inhibitors, including those at key amino acid positions 28, 30, 31, or 93. The combination of pibrentasvir with HCV inhibitors of other classes produced synergistic inhibition of HCV replication. In summary, pibrentasvir is a next-generation HCV NS5A inhibitor with potent and pan-genotypic activity, and it maintains activity against common amino acid substitutions of HCV genotypes 1 to 6 that are known to confer resistance to currently approved NS5A inhibitors." @default.
• W2588942442 created "2017-02-24" @default.
• W2588942442 creator A5017869801 @default.
• W2588942442 creator A5026542932 @default.
• W2588942442 creator A5031450708 @default.
• W2588942442 creator A5035070077 @default.
• W2588942442 creator A5035416018 @default.
• W2588942442 creator A5054725734 @default.
• W2588942442 creator A5063867964 @default.
• W2588942442 creator A5064702968 @default.
• W2588942442 creator A5073876921 @default.
• W2588942442 creator A5074957787 @default.
• W2588942442 creator A5078071322 @default.
• W2588942442 creator A5081266398 @default.
• W2588942442 creator A5085966620 @default.
• W2588942442 creator A5086039311 @default.
• W2588942442 creator A5086640568 @default.
• W2588942442 date "2017-05-01" @default.
• W2588942442 modified "2023-10-17" @default.
• W2588942442 title "<i>In Vitro</i> Antiviral Activity and Resistance Profile of the Next-Generation Hepatitis C Virus NS5A Inhibitor Pibrentasvir" @default.
• W2588942442 cites W1557711811 @default.
• W2588942442 cites W1826210767 @default.
• W2588942442 cites W1941458012 @default.
• W2588942442 cites W1980154502 @default.
• W2588942442 cites W1982154889 @default.
• W2588942442 cites W1983369983 @default.
• W2588942442 cites W1985857665 @default.
• W2588942442 cites W1986445856 @default.
• W2588942442 cites W1995591620 @default.
• W2588942442 cites W2002927032 @default.
• W2588942442 cites W2003780225 @default.
• W2588942442 cites W2009780339 @default.
• W2588942442 cites W2012365423 @default.
• W2588942442 cites W2022869504 @default.
• W2588942442 cites W2028523330 @default.
• W2588942442 cites W2031722715 @default.
• W2588942442 cites W2042063943 @default.
• W2588942442 cites W2054768505 @default.
• W2588942442 cites W2091247559 @default.
• W2588942442 cites W2096347191 @default.
• W2588942442 cites W2104462601 @default.
• W2588942442 cites W2106172816 @default.
• W2588942442 cites W2115466322 @default.
• W2588942442 cites W2115610036 @default.
• W2588942442 cites W2116514247 @default.
• W2588942442 cites W2133036275 @default.
• W2588942442 cites W2141839071 @default.
• W2588942442 cites W2147940657 @default.
• W2588942442 cites W2148864053 @default.
• W2588942442 cites W2151898297 @default.
• W2588942442 cites W2163028749 @default.
• W2588942442 cites W2206868666 @default.
• W2588942442 cites W2226967627 @default.
• W2588942442 cites W2277092291 @default.
• W2588942442 cites W2277765825 @default.
• W2588942442 cites W2279928089 @default.
• W2588942442 cites W2292090508 @default.
• W2588942442 cites W2339964390 @default.
• W2588942442 cites W2340016532 @default.
• W2588942442 cites W2487282667 @default.
• W2588942442 cites W2512713680 @default.
• W2588942442 cites W2523240064 @default.
• W2588942442 doi "https://doi.org/10.1128/aac.02558-16" @default.
• W2588942442 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5404558" @default.
• W2588942442 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28193664" @default.
• W2588942442 hasPublicationYear "2017" @default.
• W2588942442 type Work @default.
• W2588942442 sameAs 2588942442 @default.
• W2588942442 citedByCount "112" @default.
• W2588942442 countsByYear W25889424422017 @default.
• W2588942442 countsByYear W25889424422018 @default.
• W2588942442 countsByYear W25889424422019 @default.
• W2588942442 countsByYear W25889424422020 @default.
• W2588942442 countsByYear W25889424422021 @default.
• W2588942442 countsByYear W25889424422022 @default.
• W2588942442 countsByYear W25889424422023 @default.
• W2588942442 crossrefType "journal-article" @default.
• W2588942442 hasAuthorship W2588942442A5017869801 @default.
• W2588942442 hasAuthorship W2588942442A5026542932 @default.
• W2588942442 hasAuthorship W2588942442A5031450708 @default.
• W2588942442 hasAuthorship W2588942442A5035070077 @default.
• W2588942442 hasAuthorship W2588942442A5035416018 @default.
• W2588942442 hasAuthorship W2588942442A5054725734 @default.
• W2588942442 hasAuthorship W2588942442A5063867964 @default.
• W2588942442 hasAuthorship W2588942442A5064702968 @default.
• W2588942442 hasAuthorship W2588942442A5073876921 @default.
• W2588942442 hasAuthorship W2588942442A5074957787 @default.
• W2588942442 hasAuthorship W2588942442A5078071322 @default.
• W2588942442 hasAuthorship W2588942442A5081266398 @default.
• W2588942442 hasAuthorship W2588942442A5085966620 @default.
• W2588942442 hasAuthorship W2588942442A5086039311 @default.
• W2588942442 hasAuthorship W2588942442A5086640568 @default.
• W2588942442 hasBestOaLocation W25889424421 @default.
• W2588942442 hasConcept C104317684 @default.
• W2588942442 hasConcept C135763542 @default.
• W2588942442 hasConcept C159047783 @default.
• W2588942442 hasConcept C18103114 @default.
• W2588942442 hasConcept C22744801 @default.
• W2588942442 hasConcept C2522874641 @default.
• W2588942442 hasConcept C2776408679 @default.

• next