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- W2588948315 abstract "Toll-like receptor (TLR) ligands are strongly considered immune-adjuvants for cancer immunotherapy and have been shown to exert direct anti-cancer effects. This study was performed to evaluate the synergistic anti-cancer and anti-metastatic effects of the TLR7 agonist imiquimod (IMQ) during radiotherapy for melanoma. The pretreatment of B16F10 or B16F1 cells with IMQ combined with γ-ionizing radiation (IR) led to enhanced cell death via autophagy, as demonstrated by increased expression levels of autophagy-related genes, and an increased number of autophagosomes in both cell lines. The results also confirmed that the autophagy process was accelerated via the reactive oxygen species (ROS)-mediated MAPK and NF-κB signaling pathway in the cells pretreated with IMQ combined with IR. Mice subcutaneously injected with melanoma cells showed a reduced tumor growth rate after treatment with IMQ and IR. Treatment with 3-methyladenine (3-MA), ameliorated the anti-cancer effect of IMQ combined with IR. Additionally, the combination therapy enhanced anti-cancer immunity, as demonstrated by an increased number of CD8+ T cells and decreased numbers of regulatory T cells (Treg) and myeloid-derived suppressor cells (MDSCs) in the tumor lesions. Moreover, the combination therapy decreased the number of metastatic nodules in the lungs of mice that were injected with B16F10 cells via the tail vein. In addition, the combination therapy enhanced systemic anti-cancer immunity by increasing the abundances of T cell populations expressing IFN-γ and TNF-α. Therefore, these findings suggest that IMQ could serve as a radiosensitizer and immune booster during radiotherapy for melanoma patients." @default.
- W2588948315 created "2017-02-24" @default.
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- W2588948315 date "2017-02-15" @default.
- W2588948315 modified "2023-10-12" @default.
- W2588948315 title "The TLR7 agonist imiquimod induces anti-cancer effects via autophagic cell death and enhances anti-tumoral and systemic immunity during radiotherapy for melanoma" @default.
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- W2588948315 cites W1923611821 @default.
- W2588948315 cites W1961652302 @default.
- W2588948315 cites W1965917728 @default.
- W2588948315 cites W1973251492 @default.
- W2588948315 cites W1983954904 @default.
- W2588948315 cites W1984484036 @default.
- W2588948315 cites W1985317418 @default.
- W2588948315 cites W1990461051 @default.
- W2588948315 cites W1993420926 @default.
- W2588948315 cites W1994823455 @default.
- W2588948315 cites W1995582211 @default.
- W2588948315 cites W1995586746 @default.
- W2588948315 cites W2002157461 @default.
- W2588948315 cites W2004150448 @default.
- W2588948315 cites W2005488333 @default.
- W2588948315 cites W2006846913 @default.
- W2588948315 cites W2008373353 @default.
- W2588948315 cites W2009043654 @default.
- W2588948315 cites W2009801524 @default.
- W2588948315 cites W2023563981 @default.
- W2588948315 cites W2023623233 @default.
- W2588948315 cites W2026349319 @default.
- W2588948315 cites W2038554653 @default.
- W2588948315 cites W2043812762 @default.
- W2588948315 cites W2051175209 @default.
- W2588948315 cites W2053454833 @default.
- W2588948315 cites W2063874265 @default.
- W2588948315 cites W2066068067 @default.
- W2588948315 cites W2070968699 @default.
- W2588948315 cites W2073557608 @default.
- W2588948315 cites W2076055196 @default.
- W2588948315 cites W2082865800 @default.
- W2588948315 cites W2082914082 @default.
- W2588948315 cites W2086559292 @default.
- W2588948315 cites W2090961350 @default.
- W2588948315 cites W2093504658 @default.
- W2588948315 cites W2095386620 @default.
- W2588948315 cites W2112748255 @default.
- W2588948315 cites W2117692326 @default.
- W2588948315 cites W2118315567 @default.
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- W2588948315 cites W2119800239 @default.
- W2588948315 cites W2123662098 @default.
- W2588948315 cites W2124511866 @default.
- W2588948315 cites W2130350123 @default.
- W2588948315 cites W2133403756 @default.
- W2588948315 cites W2139246522 @default.
- W2588948315 cites W2140368744 @default.
- W2588948315 cites W2152281757 @default.
- W2588948315 cites W2154536286 @default.
- W2588948315 cites W2155850584 @default.
- W2588948315 cites W2156320420 @default.
- W2588948315 cites W2157058802 @default.
- W2588948315 cites W2158885476 @default.
- W2588948315 cites W2160193764 @default.
- W2588948315 cites W2160934660 @default.
- W2588948315 cites W2163035374 @default.
- W2588948315 cites W2185247439 @default.
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- W2588948315 doi "https://doi.org/10.18632/oncotarget.15326" @default.
- W2588948315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5421900" @default.
- W2588948315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28212561" @default.
- W2588948315 hasPublicationYear "2017" @default.
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