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• W2588966492 endingPage "2132" @default.
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• W2588966492 abstract "Aminopeptidase A (APA) is expressed in glomerular podocytes and tubular epithelia and metabolizes angiotensin II (AngII), a peptide known to promote glomerulosclerosis. In this study, we tested whether APA expression changes in response to progressive nephron loss or whether APA exerts a protective role against glomerular damage and during AngII-mediated hypertensive kidney injury. At advanced stages of FSGS, fawn-hooded hypertensive rat kidneys exhibited distinctly increased APA staining in areas of intact glomerular capillary loops. Moreover, BALB/c APA-knockout (KO) mice injected with a nephrotoxic serum showed persistent glomerular hyalinosis and albuminuria 96 hours after injection, whereas wild-type controls achieved virtually full recovery. We then tested the effect of 4-week infusion of AngII (400 ng/kg per minute) in APA-KO and wild-type mice. Although we observed no significant difference in achieved systolic BP, AngII-treated APA-KO mice developed a significant rise in albuminuria not observed in AngII-treated wild-type mice along with increased segmental and global sclerosis and/or collapse of juxtamedullary glomeruli, microcystic tubular dilation, and tubulointerstitial fibrosis. In parallel, AngII treatment significantly increased the kidney AngII content and attenuated the expression of podocyte nephrin in APA-KO mice but not in wild-type controls. These data show that deficiency of APA increases susceptibility to glomerular injury in BALB/c mice. The augmented AngII-mediated kidney injury observed in association with increased intrarenal AngII accumulation in the absence of APA suggests a protective metabolizing role of APA in AngII-mediated glomerular diseases." @default.
• W2588966492 created "2017-02-24" @default.
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• W2588966492 date "2017-02-15" @default.
• W2588966492 modified "2023-10-12" @default.
• W2588966492 title "Deficiency of the Angiotensinase Aminopeptidase A Increases Susceptibility to Glomerular Injury" @default.
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• W2588966492 cites W1527794992 @default.
• W2588966492 cites W1742438215 @default.
• W2588966492 cites W1843636303 @default.
• W2588966492 cites W186341176 @default.
• W2588966492 cites W1965986695 @default.
• W2588966492 cites W1968822909 @default.
• W2588966492 cites W1973191917 @default.
• W2588966492 cites W1973551456 @default.
• W2588966492 cites W1986525711 @default.
• W2588966492 cites W1989473142 @default.
• W2588966492 cites W2000579954 @default.
• W2588966492 cites W2001822708 @default.
• W2588966492 cites W2014491132 @default.
• W2588966492 cites W2016300658 @default.
• W2588966492 cites W2017313215 @default.
• W2588966492 cites W2018154498 @default.
• W2588966492 cites W2018509996 @default.
• W2588966492 cites W2018920164 @default.
• W2588966492 cites W2023208472 @default.
• W2588966492 cites W2023802359 @default.
• W2588966492 cites W2025312434 @default.
• W2588966492 cites W2026425573 @default.
• W2588966492 cites W2027388581 @default.
• W2588966492 cites W2030676731 @default.
• W2588966492 cites W2031085640 @default.
• W2588966492 cites W2032115561 @default.
• W2588966492 cites W2036540033 @default.
• W2588966492 cites W2045904863 @default.
• W2588966492 cites W2046110715 @default.
• W2588966492 cites W2052956765 @default.
• W2588966492 cites W2053910475 @default.
• W2588966492 cites W2056763550 @default.
• W2588966492 cites W2059287255 @default.
• W2588966492 cites W2069670129 @default.
• W2588966492 cites W2071299611 @default.
• W2588966492 cites W2076722320 @default.
• W2588966492 cites W2093593621 @default.
• W2588966492 cites W2098387143 @default.
• W2588966492 cites W2099399150 @default.
• W2588966492 cites W2100558876 @default.
• W2588966492 cites W2100766003 @default.
• W2588966492 cites W2104103470 @default.
• W2588966492 cites W2104899725 @default.
• W2588966492 cites W2107940325 @default.
• W2588966492 cites W2110826103 @default.
• W2588966492 cites W2111560027 @default.
• W2588966492 cites W2113322063 @default.
• W2588966492 cites W2117892119 @default.
• W2588966492 cites W2121475491 @default.
• W2588966492 cites W2124512894 @default.
• W2588966492 cites W2128352469 @default.
• W2588966492 cites W2129053556 @default.
• W2588966492 cites W2130345672 @default.
• W2588966492 cites W2130859708 @default.
• W2588966492 cites W2131460202 @default.
• W2588966492 cites W2136934622 @default.
• W2588966492 cites W2138002856 @default.
• W2588966492 cites W2143069310 @default.
• W2588966492 cites W2144489880 @default.
• W2588966492 cites W2145872553 @default.
• W2588966492 cites W2149055198 @default.
• W2588966492 cites W2149482537 @default.
• W2588966492 cites W2155946474 @default.
• W2588966492 cites W2157230648 @default.
• W2588966492 cites W2157734027 @default.
• W2588966492 cites W2167781127 @default.
• W2588966492 cites W2168882952 @default.
• W2588966492 cites W2242222699 @default.
• W2588966492 cites W2257012348 @default.
• W2588966492 cites W2289592036 @default.
• W2588966492 cites W2401347287 @default.
• W2588966492 cites W2407672446 @default.
• W2588966492 cites W2413237677 @default.
• W2588966492 cites W2415676963 @default.
• W2588966492 cites W2416952141 @default.
• W2588966492 cites W2463115665 @default.
• W2588966492 cites W2615684303 @default.
• W2588966492 cites W2406422701 @default.
• W2588966492 doi "https://doi.org/10.1681/asn.2016111166" @default.
• W2588966492 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5491295" @default.
• W2588966492 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28202497" @default.

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