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• W2588974872 abstract "The Wnt/β-catenin signaling pathway plays important roles during various cellular functions including survival and proliferation of immune cells. The critical role of this pathway in conventional T cell development is established but little is known about its contributions to innate T cell development. In this study, we found that β-catenin level, an indication of the strength of Wnt/β-catenin signaling, is regulated during invariant NKT (iNKT) cell development. β-catenin levels were greatly increased during iNKT cell selection from double positive thymocytes to Stage 0 of iNKT cell development and during subsequent development to Stage 1. Thereafter, β-catenin levels decrease from Stage 2, which is essential for the terminal maturation of iNKT cells. Failure to dampen Wnt/β-catenin signaling as in mice expressing a stabilized active form of β-catenin (CATtg) resulted in increased Stage 2 and decreased Stage 3 iNKT cells. Inefficient transition from Stage 2 to 3 in CATtg iNKT cells seems to be contributed by poor expression of IL-15R (CD122) and transcription factor T-bet, both of which are necessary for terminal maturation of iNKT cells in the thymus. Consequently, IFN-γ+ iNKT cells were greatly reduced in CATtg mice. Together, our findings reveal that proper regulation of β-catenin and in turn Wnt signaling plays an important role in the terminal maturation and function of iNKT cells." @default.
• W2588974872 created "2017-02-24" @default.
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• W2588974872 date "2017-05-01" @default.
• W2588974872 modified "2023-09-26" @default.
• W2588974872 title "Temporal regulation of Wnt/β-catenin signaling is important for invariant NKT cell development and terminal maturation" @default.
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• W2588974872 doi "https://doi.org/10.1016/j.molimm.2017.01.025" @default.
• W2588974872 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5385147" @default.
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