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• W2588990116 abstract "Objectives: To summarize the main points from the Brazilian’s Ministry of Health Economic Evaluations (HEE) guideline. Methods: The guideline was developed through multiple rounds of iterative work, conducted by a multidisciplinary team of specialists in health economics, and where submitted to public consultation. Results: The decision problem should be defined through a structured research question. The study can be either primary data or model-based; in the first case, there is greater internal validity, while the second generates a superior generalizability. When the study is model-based and focused on a chronic disease, a Markov model can be usually employed, except for situations that points towards the need of a discrete event simulation (such as competition of individuals for scarce resources) or a dynamic transition model (for example, vaccination models and infectious diseases with high transmission rates between individuals). The preferred time horizon is the lifetime one, and the default discount rate is 5% for both costs and effectiveness. Costs should represent the Unified Health System (SUS) perspective and can be estimated through either gross-costing or micro-costing. Results should be presented as costs per quality adjusted life years (QALYs) whenever possible, to facilitate comparison with other studies. Sensitivity analyses should be widely employed, in order to evaluate the impact of uncertainty in the results produced by the model. Conclusions: It is expected that, with the methodological standardization proposed in this guideline, the HEE production in Brazil has gains in quality and reproducibility." @default.
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• W2588990116 date "2016-12-01" @default.
• W2588990116 modified "2023-10-18" @default.
• W2588990116 title "Diretriz metodológica para estudos de avaliação econômica de tecnologias em saúde no Brasil" @default.
• W2588990116 doi "https://doi.org/10.21115/jbes.v8.n3.p174-184" @default.
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