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- W2589007809 endingPage "590" @default.
- W2589007809 startingPage "582" @default.
- W2589007809 abstract "Energy homeostasis is pivotal for cell fate since metabolic regulation, cell proliferation and death are strongly dependent on the balance between catabolic and anabolic pathways. In particular, metabolic and energetic changes have been observed in cancer cells even before the discovery of oncogenes and tumor suppressors, but have been neglected for a long time. Instead, during the past 20 years a renaissance of the study of tumor metabolism has led to a revised and more accurate sight of the metabolic landscape of cancer cells. In this scenario, genetic, biochemical and clinical evidences place mitochondria as key actors in cancer metabolic restructuring, not only because there are energy and biosynthetic intermediates manufacturers, but also because occurrence of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA has been associated to different types of cancer. Here we provide an overview of the possible mechanisms modulating mitochondrial energy production and homeostasis in the intriguing scenario of neoplastic cells, focusing on the double-edged role of 5′-AMP activated protein kinase in cancer metabolism. This article is part of a Special Issue entitled Mitochondria in Cancer, edited by Giuseppe Gasparre, Rodrigue Rossignol and Pierre Sonveaux." @default.
- W2589007809 created "2017-02-24" @default.
- W2589007809 creator A5009635225 @default.
- W2589007809 creator A5023379236 @default.
- W2589007809 creator A5030285343 @default.
- W2589007809 creator A5056609149 @default.
- W2589007809 date "2017-08-01" @default.
- W2589007809 modified "2023-10-16" @default.
- W2589007809 title "Mitochondrial metabolism and energy sensing in tumor progression" @default.
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