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- W2589011220 abstract "Background: The optimal sequential therapy for metastatic castration-resistant prostate cancer (mCRPC) is controversial. Some studies have claimed cross-resistance between abiraterone and enzalutamide. We assessed the effects of abiraterone for mCRPC after treatment with enzalutamide in Japanese patients. Methods: We retrospectively evaluated the clinical and post-treatment outcomes of eight patients (median age, 79 [54 – 81] y) with mCRPC that was treated with enzalutamide followed by abiraterone between October 2014 and December 2015. Results: The median duration of enzalutamide therapy was 3.0 (0.2 - 5.4) months and the serum PSA level declined by > 50% in 3 (37.5%) patients. The median duration of subsequent abiraterone therapy was 3.6 (1.2 - 5.4) months, during which the median serum PSA was 16 (3-212) ng/ml in 8 patients. PSA did not decline>50% in any patient; rather, the PSA levels probably increased in all patients during this time. Only two patients were treatable with chemotherapy after receiving abiraterone and their PSA levels continued to fall by > 50%. Conclusions: Abiraterone does not seem to confer any benefit upon Japanese patients undergoing treatment with enzalutamide. Therefore, chemotherapy should perhaps be considered instead." @default.
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- W2589011220 date "2016-11-01" @default.
- W2589011220 modified "2023-09-30" @default.
- W2589011220 title "Effects of abiraterone in Japanese men with metastatic castration-resistant prostate cancer after enzalutamide treatment" @default.
- W2589011220 doi "https://doi.org/10.1093/annonc/mdw524.010" @default.
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