FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2589029485> ?p ?o ?g. }

• W2589029485 abstract "Disturbed amyloid precursor protein (APP) processing is considered to be central to the pathogenesis of Alzheimer's disease (AD). The autosomal dominant form of the disease, familial AD (FAD), may serve as a model for the sporadic form of AD. In FAD the diagnosis of AD is reliable and presymptomatic individuals carrying FAD mutations can give valuable insights into the earliest stages of the disease where therapeutic interventions are thought to be the most effective.In the current cross-sectional study, products of APP processing (e.g., sAPPα, sAPPβ, Aβ38, Aβ40 and Aβ42) were measured in the cerebrospinal fluid (CSF) of individuals carrying one of three FAD mutations, APPswe (p.KM670/671NL), APParc (p.E693G) and PSEN1 (p.H163Y), as well as in non-mutation carriers from the same families.We observed pathological APP processing in presymptomatic carriers of FAD mutations, with different profiles of APP and Aβ isoforms in the three mutation carrier groups, APPswe (p.KM670/671NL), APParc (p.E693G) and PSEN1 (p.H163Y), except for the well-established decrease in CSF Aβ42 that was found with all mutations.These findings add to the current evidence that AD pathophysiology differs between disease-causing mutations and can be monitored in the presymptomatic disease stage by CSF analyses. This may also be important from a therapeutic standpoint, by opening a window to monitor effects of disease-modifying drugs on AD pathophysiology." @default.
• W2589029485 created "2017-02-24" @default.
• W2589029485 creator A5000752828 @default.
• W2589029485 creator A5012159562 @default.
• W2589029485 creator A5012540754 @default.
• W2589029485 creator A5020077464 @default.
• W2589029485 creator A5046426798 @default.
• W2589029485 creator A5068394264 @default.
• W2589029485 creator A5084199057 @default.
• W2589029485 creator A5087294774 @default.
• W2589029485 date "2017-02-16" @default.
• W2589029485 modified "2023-10-17" @default.
• W2589029485 title "The effects of different familial Alzheimer’s disease mutations on APP processing in vivo" @default.
• W2589029485 cites W1513565593 @default.
• W2589029485 cites W1824928054 @default.
• W2589029485 cites W1928655587 @default.
• W2589029485 cites W1965551469 @default.
• W2589029485 cites W1972025839 @default.
• W2589029485 cites W1977108519 @default.
• W2589029485 cites W1995947967 @default.
• W2589029485 cites W2001854231 @default.
• W2589029485 cites W2017779103 @default.
• W2589029485 cites W2028846933 @default.
• W2589029485 cites W2029486567 @default.
• W2589029485 cites W2029695041 @default.
• W2589029485 cites W2030641075 @default.
• W2589029485 cites W2044601342 @default.
• W2589029485 cites W2055649795 @default.
• W2589029485 cites W2062135776 @default.
• W2589029485 cites W2068193781 @default.
• W2589029485 cites W2072203507 @default.
• W2589029485 cites W2072906246 @default.
• W2589029485 cites W2073171431 @default.
• W2589029485 cites W2078123230 @default.
• W2589029485 cites W2078805862 @default.
• W2589029485 cites W2082429191 @default.
• W2589029485 cites W2094144144 @default.
• W2589029485 cites W2096410114 @default.
• W2589029485 cites W2108249261 @default.
• W2589029485 cites W2117635180 @default.
• W2589029485 cites W2129497119 @default.
• W2589029485 cites W2132693848 @default.
• W2589029485 cites W2134139278 @default.
• W2589029485 cites W2136680662 @default.
• W2589029485 cites W2141318707 @default.
• W2589029485 cites W2155483859 @default.
• W2589029485 cites W2156220037 @default.
• W2589029485 cites W2289266957 @default.
• W2589029485 doi "https://doi.org/10.1186/s13195-017-0234-1" @default.
• W2589029485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5312523" @default.
• W2589029485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28209190" @default.
• W2589029485 hasPublicationYear "2017" @default.
• W2589029485 type Work @default.
• W2589029485 sameAs 2589029485 @default.
• W2589029485 citedByCount "29" @default.
• W2589029485 countsByYear W25890294852017 @default.
• W2589029485 countsByYear W25890294852018 @default.
• W2589029485 countsByYear W25890294852019 @default.
• W2589029485 countsByYear W25890294852020 @default.
• W2589029485 countsByYear W25890294852021 @default.
• W2589029485 countsByYear W25890294852022 @default.
• W2589029485 countsByYear W25890294852023 @default.
• W2589029485 crossrefType "journal-article" @default.
• W2589029485 hasAuthorship W2589029485A5000752828 @default.
• W2589029485 hasAuthorship W2589029485A5012159562 @default.
• W2589029485 hasAuthorship W2589029485A5012540754 @default.
• W2589029485 hasAuthorship W2589029485A5020077464 @default.
• W2589029485 hasAuthorship W2589029485A5046426798 @default.
• W2589029485 hasAuthorship W2589029485A5068394264 @default.
• W2589029485 hasAuthorship W2589029485A5084199057 @default.
• W2589029485 hasAuthorship W2589029485A5087294774 @default.
• W2589029485 hasBestOaLocation W25890294851 @default.
• W2589029485 hasConcept C10162356 @default.
• W2589029485 hasConcept C104317684 @default.
• W2589029485 hasConcept C142724271 @default.
• W2589029485 hasConcept C175344181 @default.
• W2589029485 hasConcept C2776485563 @default.
• W2589029485 hasConcept C2779134260 @default.
• W2589029485 hasConcept C2779483572 @default.
• W2589029485 hasConcept C2780942790 @default.
• W2589029485 hasConcept C31705614 @default.
• W2589029485 hasConcept C501734568 @default.
• W2589029485 hasConcept C502032728 @default.
• W2589029485 hasConcept C54355233 @default.
• W2589029485 hasConcept C71924100 @default.
• W2589029485 hasConcept C86803240 @default.
• W2589029485 hasConceptScore W2589029485C10162356 @default.
• W2589029485 hasConceptScore W2589029485C104317684 @default.
• W2589029485 hasConceptScore W2589029485C142724271 @default.
• W2589029485 hasConceptScore W2589029485C175344181 @default.
• W2589029485 hasConceptScore W2589029485C2776485563 @default.
• W2589029485 hasConceptScore W2589029485C2779134260 @default.
• W2589029485 hasConceptScore W2589029485C2779483572 @default.
• W2589029485 hasConceptScore W2589029485C2780942790 @default.
• W2589029485 hasConceptScore W2589029485C31705614 @default.
• W2589029485 hasConceptScore W2589029485C501734568 @default.
• W2589029485 hasConceptScore W2589029485C502032728 @default.
• W2589029485 hasConceptScore W2589029485C54355233 @default.
• W2589029485 hasConceptScore W2589029485C71924100 @default.
• W2589029485 hasConceptScore W2589029485C86803240 @default.

• next